PROP1 - PROP paired-like homeobox 1 Gene

Also Known as CPHD2; PROP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5626

About PROP1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,992,235-177,996,242 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 109 orthologues, 50 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, Prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011]

PROP1 Products (1)

mRNA	Protein	Name
NM_006261.5	NP_006252.4	homeobox protein prophet of Pit-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23732115	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROP1 Protein Structure

Homeobox

0
100
200
226 a.a.

Protein Preferred Names	Protein Names
homeobox protein prophet of Pit-1	pituitary-specific homeodomain factor

PROP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PROP1	O75360	METTL15	Homo sapiens	A6NJ78-4	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	METTL15	Homo sapiens	A6NJ78-4	Y2H Array	32296183
Intra	PROP1	O75360	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	PROP1	O75360	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	PROP1	O75360	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	P4HA3	Homo sapiens	Q7Z4N8	Y2H Array	32296183
Intra	PROP1	O75360	P4HA3	Homo sapiens	Q7Z4N8	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	P4HA3	Homo sapiens	Q7Z4N8	Validated Y2H	32296183
Intra	PROP1	O75360	OLIG3	Homo sapiens	Q7RTU3	Validated Y2H	32296183
Intra	PROP1	O75360	TEKT5	Homo sapiens	Q96M29	Validated Y2H	32296183
Intra	PROP1	O75360	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	PROP1	O75360	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	PROP1	O75360	NR1D2	Homo sapiens	Q6NSM0	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	NR1D2	Homo sapiens	Q6NSM0	Validated Y2H	32296183
Intra	PROP1	O75360	NR1D2	Homo sapiens	Q6NSM0	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	PROP1	O75360	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	PROP1	O75360	SPMIP6	Homo sapiens	Q8NCR6	Y2H Array	32296183
Intra	PROP1	O75360	SPMIP6	Homo sapiens	Q8NCR6	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	SPMIP6	Homo sapiens	Q8NCR6	Validated Y2H	32296183
Intra	PROP1	O75360	COX6B2	Homo sapiens	Q6YFQ2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	COX6B2	Homo sapiens	Q6YFQ2	Validated Y2H	32296183
Intra	PROP1	O75360	COX6B2	Homo sapiens	Q6YFQ2	Y2H Array	32296183
Intra	PROP1	O75360	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	PROP1	O75360	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	PROP1	O75360	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	PROP1	O75360	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ACTMAP	Homo sapiens	Q5BKX5-3	Validated Y2H	32296183
Intra	PROP1	O75360	FAM168A	Homo sapiens	Q92567-2	Validated Y2H	32296183
Intra	PROP1	O75360	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	PROP1	O75360	C6orf15	Homo sapiens	Q6UXA7	Validated Y2H	32296183
Intra	PROP1	O75360	C6orf15	Homo sapiens	Q6UXA7	Y2H Array	32296183
Intra	PROP1	O75360	C6orf15	Homo sapiens	Q6UXA7	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	PROP1	O75360	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	PROP1	O75360	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TMEM42	Homo sapiens	Q69YG0	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TMEM42	Homo sapiens	Q69YG0	Validated Y2H	32296183
Intra	PROP1	O75360	TMEM42	Homo sapiens	Q69YG0	Y2H Array	32296183
Intra	PROP1	O75360	UFSP1	Homo sapiens	Q6NVU6	Validated Y2H	32296183
Intra	PROP1	O75360	UFSP1	Homo sapiens	Q6NVU6	Y2H Array	32296183
Intra	PROP1	O75360	UFSP1	Homo sapiens	Q6NVU6	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	SMUG1	Homo sapiens	Q53HV7-2	Validated Y2H	32296183
Intra	PROP1	O75360	SMUG1	Homo sapiens	Q53HV7-2	Y2H Array	32296183
Intra	PROP1	O75360	SMUG1	Homo sapiens	Q53HV7-2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Array	32296183
Intra	PROP1	O75360	ABHD11	Homo sapiens	Q8NFV4-4	Validated Y2H	32296183
Intra	PROP1	O75360	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP19-6	Homo sapiens	Q3LI70	Validated Y2H	32296183
Intra	PROP1	O75360	CIMIP2A	Homo sapiens	Q6J272	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	CIMIP2A	Homo sapiens	Q6J272	Validated Y2H	32296183
Intra	PROP1	O75360	CIMIP2A	Homo sapiens	Q6J272	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP19-1	Homo sapiens	Q8IUB9	Validated Y2H	32296183
Intra	PROP1	O75360	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	OXER1	Homo sapiens	Q8TDS5	Validated Y2H	32296183
Intra	PROP1	O75360	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	PROP1	O75360	PSMB11	Homo sapiens	A5LHX3	Y2H Array	32296183
Intra	PROP1	O75360	PSMB11	Homo sapiens	A5LHX3	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ARSA	Homo sapiens	P15289	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ARSA	Homo sapiens	P15289	Validated Y2H	32296183
Intra	PROP1	O75360	ARSA	Homo sapiens	P15289	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	PROP1	O75360	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
Intra	PROP1	O75360	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	PROP1	O75360	HNRNPF	Homo sapiens	P52597	Validated Y2H	32296183
Intra	PROP1	O75360	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	PROP1	O75360	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	PROP1	O75360	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	PROP1	O75360	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	32296183
Intra	PROP1	O75360	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	32296183
Intra	PROP1	O75360	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	PSMB4	Homo sapiens	P28070	Validated Y2H	32296183
Intra	PROP1	O75360	PSMB4	Homo sapiens	P28070	Y2H Array	32296183
Intra	PROP1	O75360	PSMB4	Homo sapiens	P28070	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TBX22	Homo sapiens	Q9Y458	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TBX22	Homo sapiens	Q9Y458	Validated Y2H	32296183
Intra	PROP1	O75360	TBX22	Homo sapiens	Q9Y458	Y2H Array	32296183
Intra	PROP1	O75360	CRYBA1	Homo sapiens	P05813	Validated Y2H	32296183
Intra	PROP1	O75360	CRYBA1	Homo sapiens	P05813	Y2H Array	32296183
Intra	PROP1	O75360	CRYBA1	Homo sapiens	P05813	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TINAGL1	Homo sapiens	Q9GZM7	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TINAGL1	Homo sapiens	Q9GZM7	Validated Y2H	32296183
Intra	PROP1	O75360	TINAGL1	Homo sapiens	Q9GZM7	Y2H Array	32296183
Intra	PROP1	O75360	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	PROP1	O75360	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	PROP1	O75360	TLE5	Homo sapiens	Q08117	Y2H	23732115
Intra	PROP1	O75360	CFAP68	Homo sapiens	Q9H5F2	Validated Y2H	32296183
Intra	PROP1	O75360	CFAP68	Homo sapiens	Q9H5F2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	CFAP68	Homo sapiens	Q9H5F2	Y2H Array	32296183
Intra	PROP1	O75360	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	PROP1	O75360	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	PROP1	O75360	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	PROP1	O75360	BATF2	Homo sapiens	Q8N1L9	Validated Y2H	32296183
Intra	PROP1	O75360	BATF2	Homo sapiens	Q8N1L9	Y2H Array	32296183
Intra	PROP1	O75360	BATF2	Homo sapiens	Q8N1L9	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	EFEMP2	Homo sapiens	O95967	Y2H Array	32296183
Intra	PROP1	O75360	EFEMP2	Homo sapiens	O95967	Validated Y2H	32296183
Intra	PROP1	O75360	HDHD3	Homo sapiens	Q9BSH5	Validated Y2H	32296183
Intra	PROP1	O75360	HDHD3	Homo sapiens	Q9BSH5	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	HDHD3	Homo sapiens	Q9BSH5	Y2H Array	32296183
Intra	PROP1	O75360	INTS11	Homo sapiens	Q5TA45	Validated Y2H	32296183
Intra	PROP1	O75360	INTS11	Homo sapiens	Q5TA45	Y2H Array	32296183
Intra	PROP1	O75360	INTS11	Homo sapiens	Q5TA45	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	PROP1	O75360	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	PROP1	O75360	SUMO1	Homo sapiens	P63165	Y2H Array	32296183
Intra	PROP1	O75360	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	SUMO1	Homo sapiens	P63165	Validated Y2H	32296183
Intra	PROP1	O75360	METTL27	Homo sapiens	Q8N6F8	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	METTL27	Homo sapiens	Q8N6F8	Validated Y2H	32296183
Intra	PROP1	O75360	METTL27	Homo sapiens	Q8N6F8	Y2H Array	32296183
Intra	PROP1	O75360	ZNF503	Homo sapiens	Q96F45	Validated Y2H	32296183
Intra	PROP1	O75360	ZNF503	Homo sapiens	Q96F45	Y2H Array	32296183
Intra	PROP1	O75360	ZNF503	Homo sapiens	Q96F45	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	32296183
Intra	PROP1	O75360	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pituitary Hormone Deficiency, Combined, 2	Panhypopituitarism Combined Pituitary Hormone Deficiency CPHD2 Ateliotic Dwarfism With Hypogonadism Pituitary Dwarfism Iii Hanhart Dwarfism Simmond'S Disease Simmonds' Disease Cphd Pituitary Hormone Deficiency, Combined Hormone Deficiency, Pituitary, Combined, Type 2 Pituitary Dwarfism Type 3 Sheehan Syndrome
Combined Pituitary Hormone Deficiencies, Genetic Forms	Congenital Hypopituitarism Pituitary Hormone Deficiency, Combined 1 Congenital Combined Pituitary Hormone Deficiency Non-Acquired Combined Pituitary Hormone Deficiency Cphd1 Familial Congenital Hypopituitarism Multiple Pituitary Hormone Deficiencies, Genetic Forms Combined Pituitary Hormone Deficiencies, Genetic Form Hormone Deficiency, Pituitary, Combined, Type 1
Non-Acquired Panhypopituitarism	Genetic Panhypopituitarism
46,Xy Partial Gonadal Dysgenesis	46,Xy Pgd 46,Xy Partial Testicular Dysgenesis
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypopituitarism	Pituitary Hypofunction Pituitary Insufficiency Pituitary Hormone Deficiency Subpituitarism Hypophyseal Dystrophy Hypohypophysism Anterior Pituitary Insufficiency Deficient Secretion Of One Or More Pituitary Hormones Hypopituitarism Syndrome Pituitary Deficiency Pituitary Failure Pituitary Insufficiency Nos Anterior Pituitary Hypofunction Deficient Secretion Of All Pituitary Hormones Hypopituitary Dwarfism Hyposomatotropic Dwarfism Hypophyseal Dwarfism Hypopituitary Cachexia Hypophyseal Short Stature Panhypopituitarism Syndrome Pituitary Cachexia Juvenile Hypopituitarism Pituitary Dwarfism Pituitary Gland Hypofunction Primary Hypopituitarism Secondary Hypogonadism Prepubertal Panhypopituitarism Prepubertal Dwarfism Postpartum Panhypopituitary Syndrome Postpartum Hypopituitarism Pituitary Short Stature Pituitary Infantilism Pituitary Hypogonadism Pituitary Hypoadrenocorticism
Pituitary Tumors	Pituitary Tumor Pituitary Neoplasms
Hypothyroidism, Congenital, Nongoitrous, 4	Tsh Deficiency CHNG4 Thyrotropin Deficiency, Isolated Pituitary Cretinism Congenital Nongoitrous Hypothyroidism 4 Isolated Thyrotropin Deficiency Thyroid-Stimulating Hormone Deficiency Hypothyroidism, Congenital, Nongoitrous 4 Thyroid-Stimulating Hormone, Deficiency Of Isolated Thyroid-Stimulating Hormone Deficiency Isolated Tsh Deficiency Hypothyroidism, Congenital, Nongoitrous, Type 4 Secondary Hypothyroidism Tsh - [Thyroid Stimulating Hormone] Deficiency
Hypogonadism
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Septooptic Dysplasia	Septo-Optic Dysplasia De Morsier Syndrome Growth Hormone Deficiency With Pituitary Anomalies SOD Pituitary Hormone Deficiency, Combined, 5 Septo-Optic Dysplasia Spectrum Septo-Optic Dysplasia With Growth Hormone Deficiency Pituitary Hormone Deficiency, Combined 5 Hypopituitarism And Septooptic 'Dysplasia' GHDPA CPHD5 Dysplasia, Septo-Optic Kallmann Syndrome
Hypogonadotropic Hypogonadism	Klinefelter Syndrome Klinefelter'S Syndrome Xxy Syndrome Xxy Trisomy Hypogonadotropism 47, Xxy Congenital Idiopathic Hypogonadotropic Hypogonadism Isolated Congenital Gonadotropin Deficiency 47,Xxy Syndrome 47, Xxy Syndrome Klinefelters Syndrome Hypogonadism Klinefelter Syndrome In Males Klinefelter Syndrome, Unspecified Klinefelter Syndrome Karyotype 47, Xxy
Empty Sella Syndrome	Empty Sella Turcica Empty Sella
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Craniopharyngioma	Neoplasm Of Rathke'S Pouch Adamantinomatous Tumor Craniopharyngeal Duct Tumor Dysodontogenic Epithelial Tumor Rathke'S Pouch Tumor
Sheehan Syndrome	Postpartum Hypopituitarism Sheehan'S Syndrome Postpartum Panhypopituitarism Postpartum Panhypopituitary Syndrome Postpartum Pituitary Necrosis Simmond'S Disease
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Pituitary Hypoplasia	Hypoplasia Of The Pituitary Gland
Tungiasis	Tunga Penetrans Infestation Chigger Flea S Penetrans Sarcopsylla Penetrans T Penetrans Tunga Penetrans Sand-Flea Infestation Jiggers Infestation Chigoe Infestation Jigger Disease
Complement Component 2 Deficiency	C2D C2 Deficiency Complement 2 Deficiency Complement Component-2
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Seckel Syndrome 5	SCKL5 Seckel Syndrome, Type 5
Microcephaly 1, Primary, Autosomal Recessive	MCPH1 Premature Chromosome Condensation Syndrome Pcc Syndrome Primary Autosomal Recessive Microcephaly 1 Microcephaly, Primary Autosomal Recessive, 1 Premature Chromosome Condensation With Microcephaly And Mental Retardation Microcephaly Vera True Microcephaly Microcephaly, Type 1, Primary, Autosomal Recessive Autosomal Recessive Primary Microcephaly
Acth Deficiency, Isolated	Adrenocorticotropic Hormone Deficiency IAD Congenital Isolated Acth Deficiency Isolated Acth Deficiency Isolated Adrenocorticotropic Hormone Deficiency Adrenocorticotropic Hormone Deficiency Adrenocorticotropic Hormone [Acth] Deficiency Secondary Adrenocortical Insufficiency
Isolated Growth Hormone Deficiency, Type Ii	Ighd Ii Isolated Growth Hormone Deficiency Type Ii IGHD2 Growth Hormone Deficiency, Isolated, Type Ii Congenital Ighd Type Ii Congenital Isolated Gh Deficiency Type Ii Congenital Isolated Growth Hormone Deficiency Type Ii Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant Growth Hormone Deficiency, Isolated, Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant Autosomal Dominant Isolated Growth Hormone Deficiency Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 2 Growth Hormone Deficiency, Isolated Autosomal Dominant Growth Hormone Deficiency, Isolated, 2 Growth Hormone Deficiency Isolated Autosomal Dominant
Hypothyroidism, Central, With Testicular Enlargement	X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement CHTE Hypothyroidism, Central, And Testicular Enlargement Igsf1 Deficiency Syndrome X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism Central Hypothyroidism And Testicular Enlargement Hypothyroidism, Central, Testicular Enlargement
Isolated Growth Hormone Deficiency	Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Pituitary Dwarfism Dwarfism, Pituitary Isolated Somatotropin Deficiency Isolated Congenital Growth Hormone Deficiency Familial Isolated Growth Hormone Deficiency Ighd Dwarfism, Growth Hormone Deficiency Growth Hormone Deficiency Dwarfism Isolated Gh Deficiency Isolated Hgh Deficiency Isolated Human Growth Hormone Deficiency Isolated Somatotropin Deficiency Disorder Dwarfism Pituitary
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Adamantinous Craniopharyngioma	Adamantinous Rathke'S Pouch Tumor Craniopharyngioma, Adamantinomatous Adamantinomatous Craniopharyngioma
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
46,Xy Sex Reversal	Swyer Syndrome Pure Gonadal Dysgenesis 46,Xy Gonadal Dysgenesis, Xy Female Type Gonadal Dysgenesis, 46,Xy 46,Xy Cgd 46,Xy Complete Gonadal Dysgenesis 46,Xy Pure Gonadal Dysgenesis 46 Xy Gonadal Dysgenesis 46, Xy Cgd 46, Xy Complete Gonadal Dysgenesis 46, Xy Pure Gonadal Dysgenesis Xy Pure Gonadal Dysgenesis Female With 46,Xy Karyotype Xy Females
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-W039899	1,2,3,4,6-Penta-O-acetyl-D-mannopyranose, 97%		99.79%	Unkown
HY-W583812	Cbz-PEG2-prop-1-yne		/	Unkown
HY-W251756	3-(2-Iodoethoxy)prop-1-yne		/	Unkown
HY-W583811	Cbz-PEG3-prop-1-yne		/	Unkown
HY-W784556	5'-DMTr-dU(Allylamine-CO-F3)-3'-CE-phosphoramidite		98.0%	Unkown
HY-N17408	(E)-2-(2-Hydroxy-4-methylpheny1)-prop-l-en-1-yl acetate		/	Unkown
HY-RS11200	PROP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W784553	Amino-modifier-C6-dC CEP		/	Unkown
HY-W784554	5'-DMTr-Amino-modifier-C6-dT-3'-CE-phosphoramidite		/	Unkown
HY-W784555	5'-DMTr-TFA-ap-dU-3'-CE-Phosphoramidite		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PROP1	RGD	RGD:628759
Mus musculus	PROP1	MGD	MGI:109330
Macaca mulatta	PROP1	VGNC	VGNC:110442
Canis familiaris	PROP1	VGNC	VGNC:45014
Bos taurus	PROP1	VGNC	VGNC:33366
Others	PROP1	NCBI