HDAC-IN-26
HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC50 value of 4.7 nM.
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- CAS No.: 2410542-97-9
- Formule: C24H28FN5O3
- Masse moléculaire:453.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | EC50 |
4.7 nM
Compound: 10
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Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by Steady-Glo luciferase assay
Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by Steady-Glo luciferase assay
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[PMID: 32676157] |
| Sf9 | IC50 |
>50 μM
Compound: 10
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Inhibition of human recombinant full length N-terminal GST-tagged HDAC5 expressed in baculovirus infected sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence
Inhibition of human recombinant full length N-terminal GST-tagged HDAC5 expressed in baculovirus infected sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence
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[PMID: 32676157] |
| Sf9 | IC50 |
>50 μM
Compound: 10
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Inhibition of human recombinant untagged HDAC11 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay
Inhibition of human recombinant untagged HDAC11 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay
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[PMID: 32676157] |
| Sf9 | IC50 |
0.47 nM
Compound: 10
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Inhibition of full length human recombinant FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 cells using FLUOR DE LYS as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay
Inhibition of full length human recombinant FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 cells using FLUOR DE LYS as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay
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[PMID: 32676157] |
Chemical Information
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CAS No. 2410542-97-9
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Masse moléculaire 453.51
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Formule C24H28FN5O3
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SMILES
FC1=C(C=CC=C1)C2=CN=C([C@H](CCCCCC(C3=NOC=C3)=O)NC(C4CN(C4)C)=O)N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC-IN-26 Related Classifications
HY-145350 Related Classifications
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