HDAC-IN-34
HDAC-IN-34 (compound 27) is a potent HDAC inhibitor, with IC50 values of 0.022 and 0.45 μM for HDAC1 and HDAC6, respectively. HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 causes cells apoptosis through p53 signaling pathway. HDAC-IN-34 exhibits significant anti-proliferation effect against HCT-116 cells, with an IC50 of 1.41 μM.
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- CAS No.: 2857097-33-5
- Formule: C24H26N6O3
- Masse moléculaire:446.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
|
HDAC1 0.022 ± 0. μM (IC50) |
HDAC6 0.45 ± 0.0 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.41 μM
Compound: 25
|
Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
|
[PMID: 37875056] |
| HCT-116 | IC50 |
1.41 μM
Compound: 25
|
Antiproliferative activity against human HCT-116 cells
Antiproliferative activity against human HCT-116 cells
|
[PMID: 37875056] |
| HepG2 | IC50 |
1.41 μM
Compound: 25
|
Antiproliferative activity against human HepG2 cells
Antiproliferative activity against human HepG2 cells
|
[PMID: 37875056] |
| HT-29 | IC50 |
1.41 μM
Compound: 25
|
Antiproliferative activity against human HT-29 cells
Antiproliferative activity against human HT-29 cells
|
[PMID: 37875056] |
| L02 | IC50 |
11.28 μM
Compound: 25
|
Cytotoxicity against human L02 cells
Cytotoxicity against human L02 cells
|
[PMID: 37875056] |
| NCM460 | IC50 |
18.47 μM
Compound: 25
|
Cytotoxicity against human NCM460 cells
Cytotoxicity against human NCM460 cells
|
[PMID: 37875056] |
Chemical Information
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CAS No. 2857097-33-5
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Masse moléculaire 446.50
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Formule C24H26N6O3
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SMILES
COC1=CC2=C(C3=C(N2CC4CCN(CC4)C5=NC=C(C=N5)C(NO)=O)C(C)=NC=C3)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)