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Cat. No.: HY-149474

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HDAC-IN-63

HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC₅₀: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC₅₀: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML).

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CAS No.: 2920046-95-1
Formule: C₂₅H₂₆Cl₂N₆O₃
Masse moléculaire:529.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

HDAC-IN-63 Chemical Structure

CAS No.: 2920046-95-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

0.844 and 30.0 nM for FLT3 and HDAC1^[1]

Voir tous les produits spécifiques à Isoform HDAC :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	IC₅₀	0.142 μM Compound: 63	Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay	[PMID: 37659198]
MOLM-13	IC₅₀	142 nM Compound: 21	Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability incubated for 48 hr by CellTiter-Glo assay Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability incubated for 48 hr by CellTiter-Glo assay	[PMID: 39094274]
MV4-11	IC₅₀	0.092 μM Compound: 63	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay	[PMID: 37659198]
MV4-11	IC₅₀	92 nM Compound: 21	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell growth Antiproliferative activity against human MV4-11 cells assessed as reduction in cell growth	[PMID: 39094274]
U-937	IC₅₀	4.538 μM Compound: 63	Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay	[PMID: 37659198]

Chemical Information

CAS No. 2920046-95-1
Masse moléculaire 529.42
Formule C₂₅H₂₆Cl₂N₆O₃
SMILES

ClC1=CC=CC(Cl)=C1CN(C=N2)C3=C2C=CC(C4=CC(NC(CCCCCCC(NO)=O)=O)=NN4)=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang Z, et al. Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. Eur J Med Chem. 2023 Aug 28;260:115759. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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HDAC-IN-63

Voir tous les produits spécifiques à Isoform HDAC

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

HDAC-IN-63 Related Classifications

HY-149474 Related Classifications