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Cat. No.: HY-156003

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HDAC-IN-64

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

HDAC-IN-64 (Compound 13) is a HDAC inhibitor. HDAC-IN-64 inhibits HDAC4/5/6/7/9 with IC₅₀s of 24, 45, 85, 31, 37 nM. HDAC-IN-64 has anti-proliferative activity and anti-migration properties on prostate cancer (PCA) cells. HDAC-IN-64 inhibits LNCaP and RWPE-1 cell growth with GI₅₀ of 0.32 and 1.1 μM respectively.

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CAS No.: 3052688-17-9
Formule: C₁₅H₈ClF₄N₇O
Masse moléculaire:413.72

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Data Sheet (267 KB)

HDAC-IN-64 Chemical Structure

CAS No.: 3052688-17-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
Pureté et documentation
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Activité biologique

Description

IC₅₀ & Target

24, 45, 85, 31, 37 nM (HDAC4/5/6/7/9)^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	GI₅₀	0.32 μM Compound: 13	Antiproliferative activity against human LNCaP cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human LNCaP cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37633202]
RWPE-1	GI₅₀	1.1 μM Compound: 13	Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37633202]

Chemical Information

CAS No. 3052688-17-9
Masse moléculaire 413.72
Formule C₁₅H₈ClF₄N₇O
SMILES

NC1=NC(Cl)=C2N=CN(CC3=CC=C(C4=NOC(C(F)(F)F)=N4)C=C3F)C2=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Moi D, et al. Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer. Eur J Med Chem. 2023 Aug 16;260:115730. [Content Brief]

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HDAC-IN-64

1 Cited Publications

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Activité biologique
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Publications (1)
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HDAC-IN-64

Publications Citing Use of MedChemExpress (MCE) HDAC-IN-64

Voir tous les produits spécifiques à Isoform HDAC

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HDAC-IN-64 Related Classifications

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