MTH1-IN-2
MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity.
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- CAS No.: 901044-91-5
- Formule: C24H27N3O5S
- Masse moléculaire:469.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
MTH1[1]
The enzyme human MTH1 is a 2-hydroxy-dATP diphosphatase. MTH1 specifically assists RAS-induced tumors in preventing tumor- suppressive effects such as senescence whilst enabling maintenance and progression of the tumor. MTH1 inhibition helps impairing tumor growth by abrogating mitogenic signaling, epithelial-mesenchymal transition (EMT), a hallmark of progressing and aggressive tumors, anoikis inhibition and PI3K/Akt-mediated pro-survival signaling. MTH1 inhibitors induce oxidative DNA lesions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 901044-91-5
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Masse moléculaire 469.55
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Formule C24H27N3O5S
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SMILES
O=C(C1=CNC2=C(C=C(S(=O)(NC3=CC=CC(OC)=C3)=O)C=C2)C1=O)NC4C(C)CCCC4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MTH1-IN-2 Related Classifications
HY-135967 Related Classifications
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