Nesvategrast
Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model.
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- CAS No.: 1621332-91-9
- Formule: C23H27F2N5O4
- Masse moléculaire:475.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
αvβ3 0.6 nM (IC50) |
αvβ6 8 nM (IC50) |
αvβ8 13 nM (IC50) |
In Vitro
Nesvategrast (0.5-4 μg; 12 days; chick chorioallantoic membrane (CAM) models) inhibits angiogenesis stimulated by basic fibroblast growth factor in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female 129SVE newborn mice with oxygen-induced retinopathy (OIR) models[1]
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Dosage:5% SF0166
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Administration:Bilateral eye topical drip 5% SF0166
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Result:Reduced new blood vessel formation.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1621332-91-9
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Masse moléculaire 475.49
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Formule C23H27F2N5O4
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SMILES
OC(C[C@@H](C1=CN=C(OC(F)F)C=C1)N2C(N(CCCC(N3)=CC=C4C3=NCCC4)CC2)=O)=O
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Synonyms
SF0166
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nesvategrast Related Classifications
HY-117133 Related Classifications
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