NVP-BQS481
NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC50: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
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- CAS No.: 1161925-41-2
- Formule: C27H33F3N4O2
- Masse moléculaire:502.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Eg5 <0.5 nM () |
Chemical Information
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CAS No. 1161925-41-2
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Masse moléculaire 502.57
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Formule C27H33F3N4O2
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SMILES
FC[C@@H](N)CCN(C(CO)=O)[C@H](C(C)(C)C)C1=NC(C2=C(F)C=CC(F)=C2)=CN1CC3=CC=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NVP-BQS481 Related Classifications
HY-177285 Related Classifications
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