Cat. No.: HY-B0291

Oxfendazole

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Oxfendazole is a sulfoxide form of fenbendazole that is effective when taken orally. Oxfendazole fights parasites and has tumor-promoting activity.

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Pureté: 98.82%
CAS No.: 53716-50-0
Formule: C₁₅H₁₃N₃O₃S
Masse moléculaire:315.35

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Oxfendazole Chemical Structure

CAS No.: 53716-50-0

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Activité biologique
- Description
- In Vivo
- Essai clinique
Chemical Information
Publications (4)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Oxfendazole is a sulfoxide form of fenbendazole that is effective when taken orally. Oxfendazole fights parasites and has tumor-promoting activity^[1]^[2]^[3].

Voir tous les produits spécifiques à Isoform Parasite :

In Vivo

Oxfendazole (30 mg/kg, oral, single dose) is effective in preventing and controlling natural infections of gastrointestinal nematodes in pigs^[1].
Oxfendazole (0-500 mg/kg, oral, 8 weeks) has the potential to promote liver tumors in rats^[2].
Pharmacokinetic parameters of Oxfendazole administered in different doses to goats through the rumen or directly into the reticulum^[3]

Route	Dose (mg/kg)	AUC (μg/mL•h)	C_max (μg/mL)	T_max (h)	βT_1/2 (h)
Intraruminal	5	12.7	0.35	12	6.5
Intraruminal	10	26.7	0.55	15.5	8.5
Intraruminal	20	35.8	0.61	17.6	9.1
Intra-abomasal	10	18.3	0.9	4.1	/

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Naturally parasitized pigs^[1]
Dosage:

30 mg/kg; single dose
Administration:

Oral
Result:

Was effective against natural infections in piglets caused by adult roundworms, esophageal tapeworms, pig tapeworms, and giant roundworms.

Animal Model:

Fisher 344 rat^[2]
Dosage:

0, 10, 100, 250, 500 mg/kg; 8 weeks
Administration:

Oral
Result:

Led to an increase in relative liver weight, with noticeable hypertrophy of centrilobular hepatocytes, a significant increase in smooth endoplasmic reticulum in liver cells, and a marked rise in the number of placental form glutathione S-transferase positive single cells.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 53716-50-0
Appearance Solid
Masse moléculaire 315.35
Formule C₁₅H₁₃N₃O₃S
Color White to off-white
SMILES

O=C(OC)NC1=NC2=CC=C(S(C3=CC=CC=C3)=O)C=C2N1
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (4)

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ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Commun Biol

Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. [Abstract]

2024 Jan 24;7(1):123. PMID: 38267545
bioRxiv

2020 Jun.

Solvant et solubilité

In Vitro:

DMSO : 31.25 mg/mL (99.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.67 mg/mL (2.12 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1711 mL

15.8554 mL

31.7108 mL

5 mM

0.6342 mL

3.1711 mL

6.3422 mL

10 mM

0.3171 mL

1.5855 mL

3.1711 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (6.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (6.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
SDS (622 KB)
- English - EN (622 KB)
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- Deutsch - DE (622 KB)
- Norwegian - NO (622 KB)
- Español - ES (622 KB)
- Swedish - SV (622 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Alvarez, L., et al., Efficacy of a single high oxfendazole dose against gastrointestinal nematodes in naturally infected pigs. Veterinary parasitology, 2013. 194(1): p. 70-74. [Content Brief]

[2]. K Mitsumori, et al. Liver Tumour-promoting Effects of oxfendazole in rats. Food Chem Toxicol. 1997 Aug;35(8):799-806. [Content Brief]

[3]. N C Sangster, et al. Disposition of oxfendazole in goats and efficacy compared with sheep. Res Vet Sci. 1991 Nov;51(3):258-63. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	3.1711 mL	15.8554 mL	31.7108 mL	79.2770 mL
DMSO	5 mM	0.6342 mL	3.1711 mL	6.3422 mL	15.8554 mL
	10 mM	0.3171 mL	1.5855 mL	3.1711 mL	7.9277 mL
	15 mM	0.2114 mL	1.0570 mL	2.1141 mL	5.2851 mL
	20 mM	0.1586 mL	0.7928 mL	1.5855 mL	3.9638 mL
	25 mM	0.1268 mL	0.6342 mL	1.2684 mL	3.1711 mL
	30 mM	0.1057 mL	0.5285 mL	1.0570 mL	2.6426 mL
	40 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9819 mL
	50 mM	0.0634 mL	0.3171 mL	0.6342 mL	1.5855 mL
	60 mM	0.0529 mL	0.2643 mL	0.5285 mL	1.3213 mL
	80 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.9910 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Oxfendazole

4 Cited Publications

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Oxfendazole

Mass Spectrometry Human Metabolite Library

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Anti-Infection Compound Library

Anti-Cancer Compound Library

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Publications Citing Use of MedChemExpress (MCE) Oxfendazole

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Publications (4)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Oxfendazole

Mass Spectrometry Human Metabolite Library

Animal Drug Library

Anti-Infection Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Antiparasitic Compound library

Rare Diseases Drug Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Oxfendazole

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Publications (4)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Oxfendazole Related Classifications

HY-B0291 Related Classifications