Peucedanin
Based on 1 Customer Validation
Peucedanin is an orally active insect growth inhibitor and coumarin compound. Peucedanin reduces Hsp27 and Hsp72 expression and blocks Ca2+ channel activity. Peucedanin induces Apoptosis and necrosis. Peucedanin reduces the relative growth rate and consumption rate of Spodoptera littoralis larvae. Peucedanin can be used in research on cervical cancer.
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- CAS No.: 133-26-6
- Formule: C15H14O4
- Masse moléculaire:258.27
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
[2]|
HSP27 |
Hsp72 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa B cells
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Concentration:1, 5, 10, and 15 μg/mL
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Incubation Time:5 h and 24 h
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Result:Hoechst 33342 apoptosis was 0.13% at 1 μg/mL (5 h), 0.25% at 5 μg/mL (5 h), 0.20% at 10 μg/mL (5 h), 0.60% at 15 μg/mL (5 h), 0.15% at 5 μg/mL (24 h), 0.20% at 10 μg/mL (24 h), and 1.70% at 15 μg/mL (24 h).
Annexin V apoptosis was 4.65% at 1 μg/mL (5 h), 4.80% at 5 μg/mL (5 h), 3.00% at 10 μg/mL (5 h), 8.35% at 15 μg/mL (5 h), 2.05% at 1 μg/mL (24 h), 4.80% at 5 μg/mL (24 h), 1.90% at 10 μg/mL (24 h), and 11.4% at 15 μg/mL (24 h).
PI necrosis was 0.2% at 1 μg/mL (5 h), 0.5% at 5 μg/mL (5 h), 0.6% at 10 μg/mL (5 h), 0.5% at 15 μg/mL (5 h), 0.30% at 1 μg/mL (24 h), 0.40% at 5 μg/mL (24 h), 0.90% at 10 μg/mL (24 h), and 0.90% at 15 μg/mL (24 h).
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Cell Line:HeLa B cells
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Concentration:15 μg/mL
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Incubation Time:5 h and 24 h
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Result:Hsp72 expression was inhibited by 77.5% after 24 h at 15 μg/mL.
Hsp27 was diminished by 74.0% after 5 h at 15 μg/mL compared with control.
In Vivo
Peucedanin (3 μmol/g fresh wt; oral; three days) slightly decreases RGR and RCR in second-instar Spodoptera littoralis larvae[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:laboratory colony (neonate larvae)[1]
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Dosage:1.0, 2.0, 3.0, 4.0, and 5.0 μmol/g fresh wt
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Administration:oral; continuous; six days
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Result:At 1, 2, 3, 4, and 5 μmol/g fresh wt, larval growth was 68%, 23%, 22%, 18%, and 8% of control, respectively.
No larvae died during the bioassay.
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Animal Model:laboratory colony (second-instar larvae)[1]
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Dosage:3 μmol/g fresh wt
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Administration:oral; three days
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Result:At 3 μmol/g fresh wt, weight gain was 10.81 mg dry wt, diet consumed was 42.46 mg dry wt, RGR was 0.66 mg/mg/day, and RCR was 2.56 mg/mg/day.
RGR and RCR slightly decreased relative to control.
Chemical Information
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CAS No. 133-26-6
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Appearance Solid
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Masse moléculaire 258.27
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Formule C15H14O4
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SMILES
O=C1C=CC2=CC3=C(OC(C(C)C)=C3OC)C=C2O1
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Peucedanin Related Classifications
HY-N7855 Related Classifications
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