Plazomicin
Based on 1 publication(s) in Google Scholar
Plazomicin (ACHN 490) is a semi-synthetic aminoglycoside Antibiotic. Plazomicin acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin is not modified by various common aminoglycoside-modifying enzymes. Plazomicin selectively inhibits MATE2-K. Plazomicin exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales.
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- CAS No.: 1154757-24-0
- Formule: C25H48N6O10
- Masse moléculaire:592.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Plazomicin
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Activité biologique
Description
In Vitro
Plazomicin exhibits MIC50/90 = 0.25-0.5 μg/mL/0.5-1 μg/mL Against Klebsiella, Escherichia, Enterobacter, Serratia, and Citrobacter species[1].
Plazomicin selectively inhibits MATE2-K and to a lesser extent MATE1, and OCT2, which are important transporters involved with tubular secretion[1].
Plazomicin (18 h) retains antibacterial activity against most aminoglycoside modifying enzyme-expressing E. coli BW25113 and E. coli BW25113 ΔbamB ΔtolC strains[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1154757-24-0
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Masse moléculaire 592.68
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Formule C25H48N6O10
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SMILES
O[C@H]([C@H]([C@@](C)(O)CO1)NC)[C@@]1([H])O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@@]3([H])OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC([C@@H](O)CCN)=O
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Synonyms
ACHN 490
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Pureté et documentation
Références
[1]. Clark JA, et al. Plazomicin: a new aminoglycoside in the fight against antimicrobial resistance. Ther Adv Infect Dis. 2020;7:2049936120952604. Published 2020 Sep 4. [Content Brief]
[2]. Cox G, et al. Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes. ACS Infect Dis. 2018;4(6):980-987. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Plazomicin Related Classifications
HY-16955 Related Classifications
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Keywords
- Plazomicin
- 1154757-24-0
- ACHN 490
- ACHN490
- ACHN-490
- Antibiotic
- Bacterial
- complicated urinary tract infections
- MATE2-K
- nephrotoxicity
- 16S rRNA ribosomal methyltransferases
- acute pyelonephritis
- carbapenem-resistant Enterobacteriaceae
- aminoglycoside acetyltransferase AAC(2')-Ia
- aminoglycoside phosphotransferase APH(2'')-IVa
- ototoxicity
- Escherichia coli
- Inhibitor
- inhibitor
- inhibit