Saccharolactone
Based on 1 publication(s) in Google Scholar
Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM).
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- CAS No.: 389-36-6
- Formule: C6H8O7
- Masse moléculaire:192.12
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Saccharolactone
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Activité biologique
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CYP1A2 <4 mM (IC50) |
CYP2D6 <4 mM (IC50) |
CYP3A4 <4 mM (IC50) |
CYP2C8 <4 mM (IC50) |
Chemical Information
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CAS No. 389-36-6
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Masse moléculaire 192.12
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Formule C6H8O7
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SMILES
OC([C@H]([C@]1([H])[C@@H]([C@H](C(O1)=O)O)O)O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Enzyme Inhib Med Chem
Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors. [Abstract]2024 Dec;39(1):2387415. PMID: 39140677
Pureté et documentation
Références
[1]. Macfadyen A, et al. D-glucaro-1,4-lactone: its excretion in the bile and urine and effect on the biliary secretion of beta-glucuronidase after oral administration in rats. Hepatology. 1989 Apr;9(4):552-6. [Content Brief]
[2]. Behera D, et al. Effect of Saccharolactone on CYP-mediated Metabolism of Xenobiotics. Drug Metab Bioanal Lett. 2023;16(2):121-132. [Content Brief]
[3]. Oleson L, et al. Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases. J Pharm Pharmacol. 2008 Sep;60(9):1175-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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