SB-203186
SB-203186 is a highly selective 5-HT4 receptor antagonist. SB-203186 exhibits a potent competitive antagonistic effect, with its pKB value being 8.3 in the isolated right atrium model of piglets. SB-203186 can dose-dependently shift the 5-HT-induced tachycardia curve to the right, and does not inhibit the maximum response. SB-203186 is an efficient 5-HT₄ antagonist in pig and human atria, but has no significant inhibitory effect in rat atria. SB-203186 can be used for the study of diseases such as arrhythmias and abnormal myocardial contraction.
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- CAS No.: 135938-17-9
- Formule: C16H20N2O2
- Masse moléculaire:272.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
5-HT4 Receptor 8.3 (pkB) |
Chemical Information
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CAS No. 135938-17-9
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Masse moléculaire 272.34
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Formule C16H20N2O2
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SMILES
O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB-203186 Related Classifications
HY-135439 Related Classifications
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