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Cat. No.: HY-N19136

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SB87-Cl

SB87-Cl is a halogenated benzophenone antibiotic that can be isolated from fungi of the genus Pestalotiopsis. SB87-Cl exhibits strong antibacterial activity against Gram-positive bacteria, but is accompanied by cytotoxicity to mammalian cells. SB87-Cl can be used in studies of Staphylococcus aureus infection, methicillin (Methicillin (HY-121544))-resistant Staphylococcus aureus (MRSA) infection, and vancomycin (Vancomycin (HY-B0671))-susceptible Enterococcus faecium (VSE) infection.

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CAS No.: 163768-83-0
Formule: C₂₀H₁₈Cl₂O₆
Masse moléculaire:425.26

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SB87-Cl Chemical Structure

CAS No.: 163768-83-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
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Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Antibiotic :

In Vitro

Bacterial InfectionAnti-cancer

Bacterial Infection

SB87-Cl (0.31-10 μg/mL; 6-8 h) exhibits antibacterial activity against Staphylococcus aureus (MIC = 2.5 μg/mL), methicillin-resistant Staphylococcus aureus (MIC = 2.5 μg/mL), and vancomycin-sensitive Enterococcus faecium (MIC = 1.25 μg/mL), but shows no inhibitory effect on vancomycin-resistant Enterococcus faecium even at concentrations up to 10 μg/mL^[1].

Anti-cancer

SB87-Cl (0.016-50 μM) exhibits cytotoxicity against A549, HeLa, HepG2, MCF-7 and Vero cells, with IC₅₀ values of 2.9, 2.1, 3.9, 4.6 and 2.4 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 163768-83-0
Masse moléculaire 425.26
Formule C₂₀H₁₈Cl₂O₆
SMILES

O=CC1=C(C=C(C(C/C=C(C)\C)=C1C(C2=C(C(Cl)=C(C)C(Cl)=C2O)O)=O)O)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganism
Chrysosporium
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Jiang Z, et al. Pestalotinones A-D, new benzophenone antibiotics from endophytic fungus Pestalotiopsis trachicarpicola SC-J551. The Journal of antibiotics. 2022 Apr;75(4):207-212. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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