TTFB
Based on 1 Customer Validation
TTFB (N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) is a selective, non-competitive zinc-activated channel (ZAC) antagonist. TTFB inhibits Zn2+- and H+-induced ZAC currents with IC50 values of 3 μM and 8.5 μM, respectively, and has an IC50 of 4.7 μM against spontaneous activity. TTFB shows no significant agonistic, antagonistic or modulatory activity towards representative classical Cys-loop receptors including m5-HT3AR, hα3β4 nAChR, hα1β2γ2S GABAAR and hα1 GlyR. TTFB can be used to investigate the physiological and pathological functions of ZAC.
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- Pureté: 99.83%
- CAS No.: 352560-76-0
- Formule: C14H15FN2OS
- Masse moléculaire:278.35
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Activité biologique
TTFB (0.1-100 μM; 30 seconds) potently inhibits Zn2+-evoked, H+-evoked, and spontaneous ZAC activity in Xenopus oocytes with IC50 values of 3.0 μM, 8.5 μM, and 4.7 μM, respectively, and mediates complete inhibition of Zn2+-induced responses[1].
TTFB (10 μM) mediates ZAC inhibition that is voltage-independent, as it inhibits H+-evoked currents similarly at -60 mV and +60 mV[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 352560-76-0
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Appearance Solid
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Masse moléculaire 278.35
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Formule C14H15FN2OS
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SMILES
O=C(NC1=NC(=CS1)C(C)(C)C)C=2C=CC=C(F)C2
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Synonyms
N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TTFB Related Classifications
HY-46286 Related Classifications
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- TTFB
- 352560-76-0
- N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide
- 5-HT Receptor
- Glycine Receptor (GlyR)
- GABA Receptor
- nAChR
- α?β?γ?S GABA? receptors
- H?
- α? glycine receptors
- Xenopus oocytes
- Zinc-Activated Channel (ZAC)
- α?β? nicotinic acetylcholine receptors
- ox-heart submitochondrial particles
- Zn2?
- 5-HT?A
- rat-heart mitochondria
- Inhibitor
- inhibitor
- inhibit