UNC5452
UNC5452 is a selective, ATP-competitive Nek1 kinase inhibitor with an IC50 of 7.1 μM. UNC5452 inhibits IKKβ kinase activity. UNC5452 can be used for research on polycystic kidney disease.
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- CAS No.: 943434-15-9
- Formule: C17H20N4O2S
- Masse moléculaire:344.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IKKβ |
NEK1 7.1 μM (IC50) |
In Vitro
UNC5452 inhibits recombinant Nek1 in a TR-FRET-based activity assay with an IC50 of 7.1 μM[1].
UNC5452 (1 μM) is a potent and selective Nek1 inhibitor (99.8% inhibition at 1 μM) with a narrow kinome profile, indicating that the 4-aryl-7-azaindole scaffold is a promising chemical starting point for Nek1-directed development[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 943434-15-9
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Masse moléculaire 344.43
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Formule C17H20N4O2S
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SMILES
O=S(=O)(NCCN(C)C)C=1C=CC(=CC1)C=2C=CN=C3NC=CC32
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC5452 Related Classifications
HY-189144 Related Classifications
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