VJ115
VJ115 is a potent ENOX1 inhibitor with an EC50 of 50 μM. By inhibiting ENOX1, VJ115 elevates NADH, which in turn downregulates the phosphorylation of p70S6K1/S6, alters the expression of c-Jun and cytoskeletal proteins, induces endothelial cells to lose polarization and migration ability, and increases caspase-3-dependent apoptosis under radiation. VJ115 can be used in studies related to solid tumors.
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- CAS No.: 929256-79-1
- Formule: C23H24N2O
- Masse moléculaire:344.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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ENOX1 50 μM (EC50) |
p70S6K1 |
VJ115 (50 μM; 2-6 h) increases the intracellular NADH fluorescence level, inhibits the formation of capillary-like tubular structures, downregulates the mRNA and protein expressions of lamin A/C and stathmin, upregulates the mRNA and protein expressions of Hup1, and reduces the protein levels of phospho-cJun and phospho-p70S6K in HUVEC cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human umbilical vein endothelial cells (HUVECs)
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Concentration:50 μM
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Incubation Time:6 h
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Result:Decreased lamin A/C mRNA by 37% relative to control.
Decreased stathmin mRNA by 88% relative to control.
Increased hypoxia up-regulated protein 1 (Hup1) mRNA by 38% relative to control.
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Cell Line:human umbilical vein endothelial cells (HUVECs)
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Concentration:50 μM
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Incubation Time:2 h; 6 h
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Result:Decreased stathmin protein by 40% relative to control after 6 h exposure.
Decreased lamin A/C protein by greater than 70% relative to control after 6 h exposure.
Increased Hup1 protein by 3.2-fold relative to control after 6 h exposure.
Reduced lamin A/C protein levels relative to control after 2 h exposure.
Inhibited phospho-cJun levels by 61% relative to control after 6 h exposure.
Downregulated phospho-p70S6K levels relative to control after 6 h exposure.
VJ115 acts as a radiation sensitizer, reducing tumor microvessel number and density and delaying syngeneic and xenograft tumor growth when combined with fractionated x-irradiation, while enhancing radiation-induced endothelial cell apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 929256-79-1
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Masse moléculaire 344.46
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Formule C23H24N2O
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SMILES
C(\C=1C=2C(N(CC3=CC=CC=C3)C1)=CC=CC2)=C/4\N5CCC(C4O)CC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VJ115 Related Classifications
HY-111089 Related Classifications
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