Vorozole
Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 129731-10-8
- Formule: C16H13ClN6
- Masse moléculaire:324.77
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
Aromatase |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| JEG-3 | IC50 |
44.2 nM
Compound: (S)-vorozole
|
Inhibition of aromatase activity in human JEG3 cells
Inhibition of aromatase activity in human JEG3 cells
|
[PMID: 18590272] |
| JEG-3 | IC50 |
29 nM
Compound: 128
|
Inhibition of aromatase (unknown origin) expressed in JEG-3 cells
Inhibition of aromatase (unknown origin) expressed in JEG-3 cells
|
[PMID: 25992880] |
| JEG-3 | IC50 |
>10000 nM
Compound: 128
|
Inhibition of STS activity (unknown origin) expressed in JEG-3 cells
Inhibition of STS activity (unknown origin) expressed in JEG-3 cells
|
[PMID: 25992880] |
Vorozole inhibits aromatase activity with an IC50s of 1.4 nM in FSH-stimulated rat granulosa cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Vorozole (p.o.; 5 days) dose-dependently reduced uterus weight and completely inhibited tumor aromatase in ovariectomized nude mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female Sprague-Dawley rats[3]
-
Dosage:0.08, 0.16, 0.31, 0.63 or 1.25 mg/kg
-
Administration:Gavage; daily (starting at 43 days of age) for 77 days; given a single i.v. dose of methylnitrosourea (MNU) (50 mg/kg body wt) after 7 days
-
Result:Caused a dose-dependent increase in body weight gain and decrease in cancer incidence, increased the insulin-like growth factor (IGF)-1, serum testosterone levels.
Chemical Information
-
CAS No. 129731-10-8
-
Masse moléculaire 324.77
-
Formule C16H13ClN6
-
SMILES
CN1N=NC2=CC=C([C@H](C3=CC=C(Cl)C=C3)N4N=CN=C4)C=C21
-
Synonyms
(+)-Vorozole; R83842
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):617-21. [Content Brief]
[2]. Wiseman LR, et al. Vorozole. Drugs Aging. 1997 Sep;11(3):245-50; discussion 251-2. [Content Brief]
[3]. Lubet RA,et al. Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model. Carcinogenesis. 1998 Aug;19(8):1345-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Vorozole Related Classifications
HY-19599 Related Classifications
Powered by Bioz