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Cat. No.: HY-116067

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VU0404251

VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis.

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CAS No.: 1276013-77-4
Formule: C₁₉H₂₃FN₂O₂
Masse moléculaire:330.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

VU0404251 Chemical Structure

CAS No.: 1276013-77-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis^[1].

Voir tous les produits spécifiques à Isoform mGluR :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	7.2 nM Compound: 8v, VU0404251	Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization	[PMID: 22981332]
HEK293	EC₅₀	70 nM Compound: 8v, VU0404251	Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization	[PMID: 22981332]

Chemical Information

CAS No. 1276013-77-4
Masse moléculaire 330.40
Formule C₁₉H₂₃FN₂O₂
SMILES

O=C(N[C@H](C)C(C)(C)C)C1=CC=C(N=C1)OCC2=CC=CC(F)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Manka JT, et al. Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6481-5. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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VU0404251

Voir tous les produits spécifiques à Isoform mGluR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VU0404251 Related Classifications

HY-116067 Related Classifications