YM-230888
YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a Ki of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models.
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- CAS No.: 446257-23-4
- Formule: C19H28N4OS
- Masse moléculaire:360.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
mGluR 1 13 nM (Ki) |
Chemical Information
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CAS No. 446257-23-4
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Masse moléculaire 360.52
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Formule C19H28N4OS
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SMILES
C1(NC2CCCCCC2)=C3C(SC(CNC[C@H]4CCCO4)=C3)=NC=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YM-230888 Related Classifications
HY-107510 Related Classifications
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