CDK2-IN-62
CDK2-IN-62 is a predicted CDK2 inhibitor. CDK2-IN-62 induces apoptosis in breast cancer cells and reduces their colony-forming ability. CDK2-IN-62 can be used for the research of breast cancer, ovarian cancer and colorectal cancer.
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- Formule: C27H21N3O2S
- Masse moléculaire:451.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
human CDK2 |
In Vitro
CDK2-IN-62 (Compound 4e) (48 h) inhibits the viability of MCF-7, A2780cis and HT-29 cells with IC50 values of 9.19, 8.21 and 18.84 μM, respectively; it shows low toxicity to normal CHO epithelial cells[1].
CDK2-IN-62 (9.19 μM; 48 h) inhibits clonal proliferation of human breast cancer MCF-7 cells[1].
CDK2-IN-62 (9.19 μM; 36 h) induces apoptosis in MCF-7 human breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 human breast cancer cells
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Concentration:9.19 μM
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Incubation Time:36 h
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Result:Increased the total percentage of apoptotic MCF-7 cells (early + late apoptosis) to 53.1%, up from 4.22% in control cells; necrotic cells accounted for 18.5% of treated cells.
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Cell Line:MCF-7 human breast cancer cells
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Concentration:9.19 μM
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Incubation Time:48 h
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Result:Significantly reduced the number of colonies formed by MCF-7 cells compared to the control group.
Chemical Information
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Masse moléculaire 451.54
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Formule C27H21N3O2S
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SMILES
N#CC1=C(N)OC(C)=C(SC2=CC=CC=C2)C31C(N(CC4=CC=CC=C4)C5=C3C=CC=C5)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK2-IN-62 Related Classifications
HY-187179 Related Classifications
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