CDK4/6-IN-13
As a cdk4/6 inhibitor. Compounds 10B and 10C showed low nanomolar activity, ideal antiproliferative activity, excellent metabolic properties and acceptable pharmacokinetics on cdk4/6.
For research use only. We do not sell to patients.
- CAS No.: 1908454-70-5
- Formula: C25H29N7O
- Molecular Weight:443.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
56.4 nM
Compound: 10b
|
Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay
|
[PMID: 32200202] |
| MDA-MB-468 | IC50 |
874.5 nM
Compound: 10b
|
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay
|
[PMID: 32200202] |
| U-87MG ATCC | IC50 |
84.6 nM
Compound: 10b
|
Antiproliferative activity against human U-87 MG cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human U-87 MG cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay
|
[PMID: 32200202] |
Chemical Information
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CAS No. 1908454-70-5
-
Molecular Weight 443.54
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Formula C25H29N7O
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SMILES
CC(C1=C(C2=CN=C(N=C2N3C=C(N=C13)C(C)C)NC4=CC=C(C=C4)N5CCNCC5)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)