Cefovecin sodium

Cat. No.: HY-117685 Purity: 99.79%: Data Sheet
COA

SDS
Handling Instructions
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Cefovecin sodium is an extended-spectrum semisynthetic cephalosporin and bactericidal agent. Cefovecin sodium exerts potent antibacterial activity against multiple bacterial. Cefovecin sodium can be used for the research of bacterial infection.

For research use only. We do not sell to patients.

Cefovecin sodium Chemical Structure

CAS No. : 141195-77-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Cefovecin sodium:

Cefovecin Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

β-lactam

In Vitro

Cefovecin sodium (0.06-32 μg/mL; 16-48 h) exhibits broad-spectrum in vitro activity against most aerobic and anaerobic bacterial clinical isolates from dogs and cats associated with skin, urinary tract, and periodontal infections, with MIC₉₀ values as low as ≤0.06 μg/ml (for Pasteurella multocida, U.S. beta-hemolytic streptococci, U.S. Streptococcus canis, and U.S. Porphyromonas spp.) and 0.25 μg/ml (for Staphylococcus intermedius, EU and U.S.), but shows negligible activity against Enterococcus spp. (MIC₉₀ >32 μg/ml) and limited activity against Acinetobacter baumannii^[1].
Cefovecin sodium (0.06-32 μg/mL; 16-48 h) exhibits bactericidal activity against most tested aerobic gram-positive and gram-negative bacterial isolates from dogs and cats, with MBC:MIC ratios ≤2 for the majority of isolates, while anaerobic isolates show higher MBC:MIC ratios^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

475.47

Formula

C₁₇H₁₈N₅NaO₆S₂

CAS No.

141195-77-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N12)=C([C@H]3OCCC3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 125 mg/mL (262.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1032 mL	10.5159 mL	21.0318 mL
5 mM	0.4206 mL	2.1032 mL	4.2064 mL
10 mM	0.2103 mL	1.0516 mL	2.1032 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.79%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (258 KB) HNMR (280 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Stegemann MR, et al. Antimicrobial activity and spectrum of cefovecin, a new extended- spectrum cephalosporin, against pathogens collected from dogs and cats in Europe and North America. Antimicrob Agents Chemother. 2006;50(7):2286-2292. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.1032 mL	10.5159 mL	21.0318 mL	52.5796 mL
	5 mM	0.4206 mL	2.1032 mL	4.2064 mL	10.5159 mL
	10 mM	0.2103 mL	1.0516 mL	2.1032 mL	5.2580 mL
	15 mM	0.1402 mL	0.7011 mL	1.4021 mL	3.5053 mL
	20 mM	0.1052 mL	0.5258 mL	1.0516 mL	2.6290 mL
	25 mM	0.0841 mL	0.4206 mL	0.8413 mL	2.1032 mL
	30 mM	0.0701 mL	0.3505 mL	0.7011 mL	1.7527 mL
	40 mM	0.0526 mL	0.2629 mL	0.5258 mL	1.3145 mL
	50 mM	0.0421 mL	0.2103 mL	0.4206 mL	1.0516 mL
	60 mM	0.0351 mL	0.1753 mL	0.3505 mL	0.8763 mL
	80 mM	0.0263 mL	0.1314 mL	0.2629 mL	0.6572 mL
	100 mM	0.0210 mL	0.1052 mL	0.2103 mL	0.5258 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.