Cephapirin hemibenzathine
Based on 1 Customer Validation
Cephapirin hemibenzathine is an intrauterine-administered, long-acting cephalosporin antibiotic suitable for the anaerobic environment of the postpartum uterus. Cephapirin hemibenzathine effectively improves the recovery of postpartum buffaloes with subclinical endometritis (SCE) and enhances their reproductive performance. Cephapirin hemibenzathine can be used for the study of subclinical endometritis in postpartum buffaloes.
For research use only. We do not sell to patients.
- Purity: 99.69%
- CAS No.: 97468-37-6
- Formula: C17H17N3O6S2·1/2C16H20N2
- Molecular Weight:543.71
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
Cephapirin hemibenzathine (500 mg, administered as an intrauterine infusion in 19.6 g ointment base at 20-33 days in milk (DIM)) significantly improves the reproductive performance of dairy cows with subclinical endometritis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Buffaloes with normal calving, aged 5-10 years, at parity 2-4, and with a body condition score (BCS) of 2.5-3.5[1]
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Dosage:500 mg
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Administration:Intrauterine, single dose
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Result:Showed significant efficacy in improving recovery and reproductive performance in postpartum buffaloes with subclinical endometritis.
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Animal Model:Lactating Holstein Friesian cows[2]
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Dosage:500 mg
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Administration:Administered as an intrauterine infusion in 19.6 g ointment base at 20-33 days in milk (DIM)
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Result:Improved reproductive performance in cows with subclinical endometritis.
Enhanced reproductive performance in all enrolled cows.
Had no significant impact on the reproductive performance of normal cows.
Chemical Information
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CAS No. 97468-37-6
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Appearance Solid
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Molecular Weight 543.71
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Formula C17H17N3O6S2·1/2C16H20N2
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Color Light yellow to yellow
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SMILES
O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](NC(CSC3=CC=NC=C3)=O)C1=O)O.C4(CNCCNCC5=CC=CC=C5)=CC=CC=C4.[1/2]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5.83 mg/mL (10.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Nehru DA, et al. Clinical efficacy of intrauterine cephapirin benzathine administration on clearance of uterine bacteria and subclinical endometritis in postpartum buffaloes. Reprod Domest Anim. 2019 Feb;54(2):317-324. [Content Brief]
[2]. Kasimanickam R, et al. The effect of a single administration of cephapirin or cloprostenol on the reproductive performance of dairy cows with subclinical endometritis. Theriogenology. 2005 Feb;63(3):818-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8392 mL | 9.1961 mL | 18.3922 mL | 45.9804 mL |
| 5 mM | 0.3678 mL | 1.8392 mL | 3.6784 mL | 9.1961 mL | |
| 10 mM | 0.1839 mL | 0.9196 mL | 1.8392 mL | 4.5980 mL |
Cephapirin hemibenzathine Related Classifications
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