CGP-74514 hydrochloride
CGP-74514 hydrochloride is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC50: 25 nM). CGP-74514 hydrochloride inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G2/M phase and induces tumor cell apoptosis. CGP-74514 hydrochloride is promising for research of bladder cancer.
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- CAS. Nr.: 481724-82-7
- Formel: C19H25Cl2N7
- Molecular Weight:422.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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CDK1/cyclinB1 25 nM (IC50) |
Chemical Information
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CAS. Nr. 481724-82-7
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Molecular Weight 422.35
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Formel C19H25Cl2N7
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SMILES
CCN1C2=NC(N[C@@H]3[C@@H](CCCC3)N)=NC(NC4=CC(Cl)=CC=C4)=C2N=C1.Cl
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Synonyms
CGP-74514A
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Furet P, et al. Structure-based design of potent CDK1 inhibitors derived from olomoucine. J Comput Aided Mol Des. 2000 Jul;14(5):403-9. [Content Brief]
[2]. Imbach P, et al. 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett. 1999 Jan 4;9(1):91-6. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CGP-74514 hydrochloride Related Classifications
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