17-HETE
17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.
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- CAS. Nr.: 128914-47-6
- Formel: C20H32O3
- Molecular Weight:320.47
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Speicherung:
Solution, -20°C, 2 years
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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CYP1B1 |
In Vitro
17-HETE (5-20 μM) promotes the development of cardiac hypertrophy in human, through increasing CY1B1 at activity and protein levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand White rabbit[2]
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Dosage:1-20 μg
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Administration:injection into artery
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Result:17S inhibited more than 70% ATPase activity at the concentration of 2 μM, while 17R enantiomer remained inactive.
Chemical Information
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CAS. Nr. 128914-47-6
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Appearance Liquid
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Molecular Weight 320.47
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Formel C20H32O3
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Color Colorless to light yellow
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SMILES
CCCC(C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Isse FA, et al., 17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749. [Content Brief]
[2]. Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
17-HETE Related Classifications
HY-116196 Related Classifications
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