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Angiotensin II human

(Synonyms: Angiotensin II; Ang II; DRVYIHPF)
266 Cited Publications
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Based on 266 publication(s) in Google Scholar

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.

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  • Reinheit : 99.98%
  • CAS. Nr.: 4474-91-3
  • Formel: C50H71N13O12
  • Molecular Weight:1046.18
  • Speicherung:

    Sealed storage, away from moisture and light, under nitrogen.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

  • Angiotensin II human Chemical Structure
    Angiotensin II human Chemical Structure
  • Experimental Validation Results for Angiotensin II human
  • Experimental Validation Results for Angiotensin II human
  • Experimental Validation Results for Angiotensin II human
  • Experimental Validation Results for Angiotensin II human
  • Experimental Validation Results for Angiotensin II human
  • Experimental Validation Results for Angiotensin II human
  • Experimental Validation Results for Angiotensin II human
  • Experimental Validation Results for Angiotensin II human
  • Experimental Validation Results for Angiotensin II human
  • Experimental Validation Results for Angiotensin II human
CAS. Nr.: 4474-91-3
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  • Angiotensin II human Chemical Structure
    Angiotensin II human Chemical Structure
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  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Nature. 2026 Sep 30:10.1038/s41586-026-11088-0.

    Customer Validation
     β-arrestin recruitment in FLAG-AT1R-Tango+ TfR1+ HTLA cells (luminescence) after 2 h pre-treatment with FLAG GTAC or Fab-Fc, then Angiotensin II (AngII) stimulation (14 h, 200 nM).

  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Nature. 2026 Sep 30:10.1038/s41586-026-11088-0.

    Customer Validation
     β-arrestin recruitment in FLAG-AT1R-Tango+ TfR1+ HTLA cells (luminescence) after 2 h pre-treatment with 50 nM FLAG GTAC or Fab-Fc, then Angiotensin II (AngII) stimulation (200 nM; 14 h).

  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Nature. 2026 Sep 30:10.1038/s41586-026-11088-0.

    Customer Validation
     Cell-surface AT1R (anti-HA) and total AT1R (GFP) over 24 h in FLAG-HA-AT1R-GFP+ TfR1+ Expi293 cells after treatment with 1 μM Angiotensin II (AngII) or 50 nM FLAG GTAC.

  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Nature. 2026 Sep 30:10.1038/s41586-026-11088-0.

    Customer Validation
     Cell-surface AT1R (anti-HA) in TfR1+ Expi293 cells expressing FLAG-HA-AT1R-GFP with AT1R WT, T282M, or TSTS/A after 1 h treatment with 1 μM Angiotensin II (AngII), 50 nM FLAG GTAC, or 10 nM AT1R GTAC.

  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Mol Cell Endocrinol. 2023 Jul 1:571:111938. [Abstract]

    Customer Validation
     Angiotensin II human (Ang II; 1 μM; 48 h) increases the expression of MFN1, t-CaMKⅡ and p-CaMKⅡ and decreases the expression of SERCA2 in NMCMs.

  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022 Dec 4;10(12):3131. [Abstract]

    Customer Validation
     Angiotensin II human (Ang II; 100 nM; 24 h) pretreatment significantly increases both the protein level of CtBP1 during 3T3-L1 adipogenesis.

  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022 Dec 4;10(12):3131. [Abstract]

    Customer Validation
     Angiotensin II human (Ang II; 100 nM; 24 h) pretreatment significantly increases both the mRNA level of CtBP1 during 3T3-L1 adipogenesis.

  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2021 Jul 21;13(603):eaaz4959. [Abstract]

    Customer Validation
     Cultured human renal 786-O cells were stimulated with vehicle, AngII (50 μM), AngII + Telmisartan (1 μM), AngII + PD123319 (50 μM) for 12 hrs. Cells were harvested and EPO protein abundance was detected by Western blot.

  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2021 Jul 21;13(603):eaaz4959. [Abstract]

    Customer Validation
     SMC was stimulated with vehicle and AngII of 10-8 M, 10-7 M, 10-6 M,10-5 M and 10-4 M, respectively, for 24 hrs. Cells were harvested and EPO protein abundance measured by Western blot.

  • 1/16

    Angiotensin II human purchased from MedChemExpress. Usage Cited in: Int J Biochem Cell Biol. 2020 Apr:121:105703. [Abstract]

    Customer Validation
     HPMCs are treated with 5.6 mM glucose (NG) or with 236 mM glucose (HG), or 100 nM AngII (AngII), or 236 mM glucose plus 10 mM valsartan (HGþvalsartan), or 100 nM AngII plus 10 mM valsartan (AngIIþvalsartan) for 24 h. The protein levels of p-mTOR, mTOR, p-4EBP1, 4EBP1, p-S6K1, and S6K1 are examined by Western blot analysis.

  • Angiotensin II human