Art. -Nr.: HY-N0046

Notoginsenoside Fe

(Synonyms: Notoginseng triterpenes; Ginsenoside Mb)

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Notoginsenoside Fe (Notoginseng triterpenes; Ginsenoside Mb) is a saponin with anti-obesity and anti-neuroblastoma activities. Notoginsenoside Fe can be isolated from leaves of Panax notoginseng. Notoginsenoside Fe specifically activates paraventricular nucleus neurons in the hypothalamus, effectively reducing body weight, improving fasting blood glucose and protecting liver function by decreasing food intake, increasing resting metabolic rate and enhancing energy expenditure. Notoginsenoside Fe also inhibits the c-Src signaling pathway, blocks the proliferation and viability of human neuroblastoma cells, while improving mitochondrial dysfunction and alleviating apoptosis. Notoginsenoside Fe can be used in studies related to diet-induced obesity and neuroblastoma.

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Reinheit: 99.99%
CAS. Nr.: 88105-29-7
Formel: C₄₇H₈₀O₁₇
Molecular Weight:917.13

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Notoginsenoside Fe Chemical Structure

CAS. Nr.: 88105-29-7

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vitro

Notoginsenoside Fe (50 μM; 24 h) significantly reduces cell viability of human neuroblastoma SH-SY5Y cells, with a weaker inhibitory effect than notoginsenoside Ft1 (HY-N0910)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

50 μM
Incubation Time:

24 h
Result:

Significantly inhibited the viability of SH-SY5Y cells, though its inhibitory effect was weaker than that of notoginsenoside Ft1.

In Vivo

Notoginsenoside Fe (10 mg/kg; i.p.; daily; 14 days) reduces diet-induced obesity in male C57BL/6 mice by decreasing body weight by 12%, reducing food intake, improving glucose tolerance, ameliorating hepatic steatosis, reducing fat mass, increasing energy expenditure, and inhibiting lipogenesis gene expression^[1].
Notoginsenoside Fe (5 mM in 2 μl per mouse; i.c.v.; single dose) reduces food intake in diet-induced obese male C57BL/6 mice and specifically activates paraventricular nucleus neurons^[1].
Notoginsenoside Fe (10 mg/kg; i.p.; daily; 6 days) has no effect on body weight, food intake, or hypothalamic neuron activation in healthy lean male C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice with Obesity (male, 6 weeks old, diet-induced obesity model)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; daily; 14 days
Result:

Reduced body weight by 12% compared to untreated diet-induced obese mice.
Significantly decreased daily food intake.
Lowered fasting blood glucose.
Improved glucose tolerance, with reduced blood glucose levels at 60, 90, and 120 minutes following glucose injection.
Ameliorated hepatic steatosis, reduced hepatic triglyceride levels, and lowered serum alanine transaminase (ALT) levels compared to untreated obese mice.
Reduced adipose tissue adipocyte size and fat mass percentage, while increasing lean mass percentage relative to body weight.
Reduced mRNA expression levels of lipogenesis-related genes FAS, CD36, SREBP-1c, and MCP-1 in white adipose tissue.
Significantly increased oxygen consumption (VO₂) and carbon dioxide production (VCO₂) in both light and dark cycles, with no change in respiratory exchange ratio (RER).

Animal Model:

C57BL/6 mice wiht Obesity (male, 6 weeks old, diet-induced obesity model, stereotaxic guide cannula implantation)^[1]
Dosage:

5 mM in 2 μl per mouse
Administration:

i.c.v.; single dose
Result:

Significantly reduced food intake within 6 hours post-injection compared to saline-treated mice.
Induced a marked increase in C-Fos-positive neuron counts in the hypothalamic paraventricular nucleus (PVH), with no change in C-Fos expression in the arcuate nucleus (ARC).

Chemical Information

CAS. Nr. 88105-29-7
Appearance Solid
Molecular Weight 917.13
Formel C₄₇H₈₀O₁₇
Color Light yellow to yellow
SMILES

C[C@]12[C@@](C)([C@]3([H])C[C@@H](O)[C@]1([H])[C@@]([H])([C@](C)(CC/C=C(C)/C)O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](CO)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)CC2)CC[C@@]([C@]3(C)CC6)([H])C(C)(C)[C@H]6O[C@@]7([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7
Synonyms

Notoginseng triterpenes; Ginsenoside Mb
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 50 mg/mL (54.52 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0904 mL

5.4518 mL

10.9036 mL

5 mM

0.2181 mL

1.0904 mL

2.1807 mL

10 mM

0.1090 mL

0.5452 mL

1.0904 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li H, et al. Notoginsenoside Fe suppresses diet induced obesity and activates paraventricular hypothalamic neurons. RSC Adv. 2019;9(3):1290-1298. Published 2019 Jan 11. [Content Brief]

[2]. Guo X, et al. Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src. Chin Med. 2025;20(1):10. Published 2025 Jan 15. [Content Brief]

[3]. Gao B, et al. p38 MAPK and ERK1/2 pathways are involved in the pro-apoptotic effect of notoginsenoside Ft1 on human neuroblastoma SH-SY5Y cells. Life Sci. 2014;108(2):63-70. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.0904 mL	5.4518 mL	10.9036 mL	27.2589 mL
	5 mM	0.2181 mL	1.0904 mL	2.1807 mL	5.4518 mL
	10 mM	0.1090 mL	0.5452 mL	1.0904 mL	2.7259 mL
	15 mM	0.0727 mL	0.3635 mL	0.7269 mL	1.8173 mL
	20 mM	0.0545 mL	0.2726 mL	0.5452 mL	1.3629 mL
	25 mM	0.0436 mL	0.2181 mL	0.4361 mL	1.0904 mL
	30 mM	0.0363 mL	0.1817 mL	0.3635 mL	0.9086 mL
	40 mM	0.0273 mL	0.1363 mL	0.2726 mL	0.6815 mL
	50 mM	0.0218 mL	0.1090 mL	0.2181 mL	0.5452 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Notoginsenoside Fe

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Alle Src Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Notoginsenoside Fe Related Classifications

HY-N0046 Related Classifications