Art. -Nr.: HY-118355

ALLM

(Synonyms: Calpain inhibitor II)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI).

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Reinheit: 98.60%
CAS. Nr.: 110115-07-6
Formel: C₁₉H₃₅N₃O₄S
Molecular Weight:401.56

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

ALLM Chemical Structure

CAS. Nr.: 110115-07-6

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Cathepsin Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>100 μM Compound: 119	Cytotoxicity against human A549 cells assessed as reduction in cell viability by neutral red uptake assay Cytotoxicity against human A549 cells assessed as reduction in cell viability by neutral red uptake assay	[PMID: 34798775]
Caco-2	CC₅₀	>100 μM Compound: 119	Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability by neutral red uptake assay Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability by neutral red uptake assay	[PMID: 34798775]
HeLa	IC₅₀	23.7 μM Compound: 2	Antiviral activity against human rhinovirus-14 in HeLa cells Antiviral activity against human rhinovirus-14 in HeLa cells	10.1016/S0960-894X(96)00537-9
MDCK	CC₅₀	>100 μM Compound: 119	Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by neutral red uptake assay Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by neutral red uptake assay	[PMID: 34798775]
Vero	CC₅₀	>100 μM Compound: 119	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by neutral red uptake assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by neutral red uptake assay	[PMID: 34798775]
Vero C1008	EC₅₀	2.07 μM Compound: 19	Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral replication incubated for 48 hrs by CPE assay Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral replication incubated for 48 hrs by CPE assay	[PMID: 37244162]

In Vivo

ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death^[2].
ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male Wistar rats (280-300g) (spinal cord injury model)^[2]
Dosage:

0.05, 0.5, and 2.5 mg/kg
Administration:

Intraperitoneally; every 24 h for 1 week
Result:

Showed significantly better motor function.

Chemical Information

CAS. Nr. 110115-07-6
Appearance Solid
Molecular Weight 401.56
Formel C₁₉H₃₅N₃O₄S
Color White to off-white
SMILES

CSCC[C@@H](C=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(C)=O)=O)=O
Synonyms

Calpain inhibitor II
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Mol Cancer

Double vulnerability of active-NRF2 lung squamous cell carcinoma to NRF2 and TRIM24. [Abstract]

2025 Jul 17;24(1):197. PMID: 40676628

Lösungsmittel & Löslichkeit

In Vitro:

DMF : ≥ 20 mg/mL (49.81 mM)

Ethanol : ≥ 20 mg/mL (49.81 mM)

DMSO : ≥ 20 mg/mL (49.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4903 mL

12.4514 mL

24.9029 mL

5 mM

0.4981 mL

2.4903 mL

4.9806 mL

10 mM

0.2490 mL

1.2451 mL

2.4903 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Stangl V, et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J. 2004 Feb;18(2):272-9. [Content Brief]

[2]. Arataki S, et al. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma. 2005 Mar;22(3):398-406. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMF / Ethanol / DMSO	1 mM	2.4903 mL	12.4514 mL	24.9029 mL	62.2572 mL
	5 mM	0.4981 mL	2.4903 mL	4.9806 mL	12.4514 mL
	10 mM	0.2490 mL	1.2451 mL	2.4903 mL	6.2257 mL
	15 mM	0.1660 mL	0.8301 mL	1.6602 mL	4.1505 mL
	20 mM	0.1245 mL	0.6226 mL	1.2451 mL	3.1129 mL
	25 mM	0.0996 mL	0.4981 mL	0.9961 mL	2.4903 mL
	30 mM	0.0830 mL	0.4150 mL	0.8301 mL	2.0752 mL
	40 mM	0.0623 mL	0.3113 mL	0.6226 mL	1.5564 mL

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ALLM

Metabolism/Protease Compound Library

Covalent Screening Library

Ubiquitination Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Protease Inhibitor Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) ALLM

Alle Cathepsin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

ALLM

Metabolism/Protease Compound Library

Covalent Screening Library

Ubiquitination Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Protease Inhibitor Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) ALLM

Alle Cathepsin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

ALLM Related Classifications

HY-118355 Related Classifications