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Art. -Nr.: HY-182907

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Antimalarial agent 60

Antimalarial agent 60 is an antimalarial agent with an IC₅₀ of 116.2 nM against asexual blood-stage parasites of Plasmodium falciparum 3D7. Antimalarial agent 60 can be used in malaria research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₈H₁₃F₄N₃O₃
Molecular Weight:395.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent 60 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Parasite Isoform-spezifische Produkte anzeigen :

In Vitro

Antimalarial agent 60 (Compound 53) (1-10 μM; 72 h) potently inhibits the asexual blood-stage Plasmodium falciparum strain 3D7, with an IC₅₀ of 116.2 nM; meanwhile, this compound exhibits extremely low cytotoxicity against human HepG2 cells, with a CC₅₀ > 20 μM and a selectivity index > 170^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 395.31
Formel C₁₈H₁₃F₄N₃O₃
SMILES

FC1=C(F)C=C(NC(N(C(CC)C(NC2=CC=C(F)C(F)=C2)=O)C3=O)=O)C3=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lohawittayanan D, et al. From Hit to Lead: Systematic Optimization of the Quinazolinedione Scaffold as Potent and Noncytotoxic Antimalarial Agents. ACS omega. 2026 Apr 21;11(15):22796-22806. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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