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Art. -Nr.: HY-178777

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BCL6-760

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC₅₀ of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker).
(Pink: BCL6 ligand (HY-179317); Blue: no E3 ligase ligand; Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3084696-50-1
Formel: C₃₆H₄₃ClN₁₀O₄
Molecular Weight:715.24

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BCL6-760 Chemical Structure

CAS. Nr.: 3084696-50-1

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Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC₅₀ of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker)^[1]. (Pink: BCL6 ligand (HY-179317); Blue: no E3 ligase ligand; Black: linker).

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

BCL6-760 inhibits OCI-LY-1 cells growth with a GI₅₀ of 1.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_0-24	F	CL	V_ss	MRT
Mice^[1]	10 mg/kg	p.o.	4.86 μM	1.3 h	15.8 μM·h	22 %	/	/	/
Mice^[1]	2 mg/kg	i.v.	/	/	14.7 μM·h	/	3.53 mL/min/kg	0.25 L/kg	1.2 h

In Vivo

BCL6-760 (15-60 mg/kg, p.o., once or twice daily for 5 days) effectively and continuously degrades the BCL6 protein in tumors, and produces significant anti-tumor effects in OCI-LY-1 tumor xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3084696-50-1
Molecular Weight 715.24
Formel C₃₆H₄₃ClN₁₀O₄
SMILES

CN(C1=NC(NC2=CC=C3N(C(N(C3=C2)CCC(C)(O)C)=O)C)=C(C=N1)Cl)C4CCN(C5=CC6=C(C(C7CCC(NC7=O)=O)=NN6C)C=C5)CC4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shunatona HP, et al. Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760. J Med Chem. 2025 Oct 23;68(20):21502-21519. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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BCL6-760

Alle PROTACs Isoform-spezifische Produkte anzeigen