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Art. -Nr.: HY-188147

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EZH2-IN-25

EZH2-IN-25 is an EZH2 inhibitor that inhibits the catalytic subunit of PRC2. EZH2-IN-25 can be used for the research of diffuse large B cell lymphoma.

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CAS. Nr.: 2636048-41-2
Formel: C₂₅H₃₀ClN₇O₂
Molecular Weight:496.00

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

EZH2-IN-25 Chemical Structure

CAS. Nr.: 2636048-41-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
Chemical Information
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Biologische Aktivität

Beschreibung

EZH2-IN-25 is an EZH2 inhibitor that inhibits the catalytic subunit of PRC2. EZH2-IN-25 can be used for the research of diffuse large B cell lymphoma^[1].

IC₅₀ & Target

^[1]

EZH2

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

In Vitro

EZH2-IN-25 (example 53) selectively targets EZH2 within the PRC2 pentameric complex, exhibiting a mechanism of inhibition distinct from SAM-competitive inhibitors and EED K27me3-pocket binders^[1].
EZH2-IN-25 selectively targets EZH2 in human cell lines, reducing H3K27me3 levels through a mechanism distinct from SAM-competitive and EED K27me3-pocket binders^[1].
EZH2-IN-25 selectively targets EZH2 and modulates proliferation of human cancer cell lines that depend on PRC2 activity to maintain cancerous growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2636048-41-2
Molecular Weight 496.00
Formel C₂₅H₃₀ClN₇O₂
SMILES

ClC1=NC=CC2=C1N=C(N[C@@H]3CC[C@H](CC3)CNC4=NC=C([C@H](C)C(NC5COC5)=O)C=N4)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dai X, et al. Inventors; Novartis AG, applicant. WO2021057853A1. 2021 Apr 01.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EZH2-IN-25

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

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Chemical Information

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EZH2-IN-25 Related Classifications

HY-188147 Related Classifications

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