Fumonisin B1
Based on 10 publication(s) in Google Scholar
Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.90%
- CAS. Nr.: 116355-83-0
- Formel: C34H59NO15
- Molecular Weight:721.83
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Speicherung:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Publications Citing Use of MedChemExpress (MCE) Fumonisin B1
More- J Hazard Mater. 2024 Oct 5:478:135580. [Abstract]
- J Transl Med. 2023 Feb 6;21(1):89. [Abstract]
- Talanta. 2023 Jun 1:258:124388. [Abstract]
- J Food Compost Anal. 2023 Aug 19, 105615.
- Microchem J. 2025 Dec 11;220:116425.
- Fish Shellfish Immunol. 2026 Nov:178:111646.
- J Virol. 2026 Mar 24;100(3):e0199125. [Abstract]
- Toxins. 2025 Aug 15;17(8):413. [Abstract]
- SSRN. 2025 Oct 6.
- Research Square Print. December 29th, 2022.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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WB
Biologische Aktivität
Beschreibung
IC50 & Target
Sphingosine N-acyltransferase[2]
In Vitro
Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells[3].
Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS. Nr. 116355-83-0
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Appearance Solid
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Molecular Weight 721.83
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Formel C34H59NO15
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Color White to light yellow
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SMILES
OC(C[C@@H](C(O)=O)CC(O[C@@H](C[C@@H](C)C[C@H](O)CCCC[C@@H](O)C[C@H](O)[C@@H](N)C)[C@@H]([C@H](C)CCCC)OC(C[C@H](C(O)=O)CC(O)=O)=O)=O)=O
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Structure Classification
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Initial Source
a toxic metabolite of Fusarium moniliforme.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (10)
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Journal Impact Factor
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Most Recent
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J Hazard Mater
The regulatory role of miR-21 in ferroptosis by targeting FTH1 and the contribution of microglia-derived miR-21 in exosomes to arsenic-induced neuronal ferroptosis. [Abstract]2024 Oct 5:478:135580. PMID: 39186845
Fumonisin B1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Oct 5:478:135580. [Abstract]
Fumonisin B1 (3 μM, 1 h), an inhibitor of ceramide synthase, effectively diminished NaAsO2-induced increases in ceramide synthesis and exosome formation in N9 cells.
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J Transl Med
Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice. [Abstract]2023 Feb 6;21(1):89. PMID: 36747238
Fumonisin B1 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 6;21(1):89. [Abstract]
The ceramide synthetase inhibitor Fumonisin B1 (10 μM; 16 h) reduced the phosphorylation of PERK and the level of CC3 in PA-treated MIN6 cells.
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Talanta
Nanobody-based magnetic chemiluminescence immunoassay for one-pot detection of ochratoxin A. [Abstract]2023 Jun 1:258:124388. PMID: 36921368 -
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J Virol
2026 Mar 24;100(3):e0199125. PMID: 41728937 -
Toxins
The Emerging Mycotoxin 2-Amino-14, 16-Dimethyloctadecan-3-ol (AOD) Alters Transcriptional Regulation and Sphingolipid Metabolism and Undergoes N-Acylation by HepG2 Cells. [Abstract]2025 Aug 15;17(8):413. PMID: 40864089
Fumonisin B1 purchased from MedChemExpress. Usage Cited in: Toxins. 2025 Aug 15;17(8):413. [Abstract]
Fumonisin B1 (FB1) (10 µM; 24 h) caused a large decrease in the d18:1/d18:0 ratio in HepG2 cells.
Fumonisin B1 purchased from MedChemExpress. Usage Cited in: Toxins. 2025 Aug 15;17(8):413. [Abstract]
Fumonisin B1 (FB1) (10 µM; 24 h) caused N-acyl-AOD to no longer be detected in HepG2 or Caco-2 cells.
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Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (69.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 16.67 mg/mL (23.09 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 18.5 mg/mL (25.63 mM); Clear solution; Need ultrasonic and warming
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7. [Content Brief]
[2]. Shephard GS, et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. Toxicon. 1996 May;34(5):527-34. [Content Brief]
[3]. Wang SK, et al. Effect of fumonisin B₁ on the cell cycle of normal human liver cells. Mol Med Rep. 2013 Jun;7(6):1970-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.3854 mL | 6.9268 mL | 13.8537 mL | 34.6342 mL |
| 5 mM | 0.2771 mL | 1.3854 mL | 2.7707 mL | 6.9268 mL | |
| 10 mM | 0.1385 mL | 0.6927 mL | 1.3854 mL | 3.4634 mL | |
| 15 mM | 0.0924 mL | 0.4618 mL | 0.9236 mL | 2.3089 mL | |
| 20 mM | 0.0693 mL | 0.3463 mL | 0.6927 mL | 1.7317 mL | |
| DMSO | 25 mM | 0.0554 mL | 0.2771 mL | 0.5541 mL | 1.3854 mL |
| 30 mM | 0.0462 mL | 0.2309 mL | 0.4618 mL | 1.1545 mL | |
| 40 mM | 0.0346 mL | 0.1732 mL | 0.3463 mL | 0.8659 mL | |
| 50 mM | 0.0277 mL | 0.1385 mL | 0.2771 mL | 0.6927 mL | |
| 60 mM | 0.0231 mL | 0.1154 mL | 0.2309 mL | 0.5772 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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