KRT3 - keratin 3 Gene
Also Known as K3; CK3; MECD2
Species: Homo sapiens
About KRT3
This gene has 1 transcript (splice variant), 72 orthologues, 68 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.
Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
KRT3 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_057088.3 | NP_476429.2 | keratin, type II cytoskeletal 3 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in intermediate filament cytoskeleton organization |
IMP
IMP: Inferred from mutant phenotype
|
9171831 | GOA |
KRT3 Protein Structure
Filament: Intermediate filament protein (197 - 512)
- 0
- 100
- 200
- 300
- 400
- 500
- 628 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
keratin, type II cytoskeletal 3 |
|
KRT3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
KRT3 | P12035 | g4xuv3_human | Homo sapiens | G4XUV3 | 32296183 | |
|
Intra
|
KRT3 | P12035 | g4xuv3_human | Homo sapiens | G4XUV3 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT37 | Homo sapiens | O76014 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT38 | Homo sapiens | O76015 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT38 | Homo sapiens | O76015 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT33B | Homo sapiens | Q14525 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT33B | Homo sapiens | Q14525 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT33B | Homo sapiens | Q14525 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT39 | Homo sapiens | Q6A163 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT39 | Homo sapiens | Q6A163 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT39 | Homo sapiens | Q6A163 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT36 | Homo sapiens | O76013-2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT36 | Homo sapiens | O76013-2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT25 | Homo sapiens | Q7Z3Z0 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT25 | Homo sapiens | Q7Z3Z0 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT25 | Homo sapiens | Q7Z3Z0 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT28 | Homo sapiens | Q7Z3Y7 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT28 | Homo sapiens | Q7Z3Y7 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT28 | Homo sapiens | Q7Z3Y7 | 32296183 | |
|
Intra
|
KRT3 | P12035 | LHX3 | Homo sapiens | Q9UBR4-2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | LHX3 | Homo sapiens | Q9UBR4-2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | LHX3 | Homo sapiens | Q9UBR4-2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | WWOX | Homo sapiens | Q9NZC7-5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | WWOX | Homo sapiens | Q9NZC7-5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | WWOX | Homo sapiens | Q9NZC7-5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT26 | Homo sapiens | Q7Z3Y9 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT26 | Homo sapiens | Q7Z3Y9 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT26 | Homo sapiens | Q7Z3Y9 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | TRIM54 | Homo sapiens | Q9BYV2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | TRIM54 | Homo sapiens | Q9BYV2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | TRIM54 | Homo sapiens | Q9BYV2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | HAUS1 | Homo sapiens | Q96CS2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | HAUS1 | Homo sapiens | Q96CS2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | HAUS1 | Homo sapiens | Q96CS2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | SAPCD2 | Homo sapiens | Q86UD0 | 32296183 | |
|
Intra
|
KRT3 | P12035 | SAPCD2 | Homo sapiens | Q86UD0 | 32296183 | |
|
Intra
|
KRT3 | P12035 | SAPCD2 | Homo sapiens | Q86UD0 | 32296183 | |
|
Intra
|
KRT3 | P12035 | C3orf62 | Homo sapiens | Q6ZUJ4 | 32296183 | |
|
Intra
|
KRT3 | P12035 | C3orf62 | Homo sapiens | Q6ZUJ4 | 32296183 | |
|
Intra
|
KRT3 | P12035 | C3orf62 | Homo sapiens | Q6ZUJ4 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT75 | Homo sapiens | O95678 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT75 | Homo sapiens | O95678 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT24 | Homo sapiens | Q2M2I5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT24 | Homo sapiens | Q2M2I5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT24 | Homo sapiens | Q2M2I5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
KRT3 | P12035 | NUP62 | Homo sapiens | P37198 | 32296183 | |
|
Intra
|
KRT3 | P12035 | NUP62 | Homo sapiens | P37198 | 32296183 | |
|
Intra
|
KRT3 | P12035 | NUP62 | Homo sapiens | P37198 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
KRT3 | P12035 | TRAF1 | Homo sapiens | Q13077 | 32296183 | |
|
Intra
|
KRT3 | P12035 | TRAF1 | Homo sapiens | Q13077 | 32296183 | |
|
Intra
|
KRT3 | P12035 | TRAF1 | Homo sapiens | Q13077 | 32296183 | |
|
Intra
|
KRT3 | P12035 | SPAG5 | Homo sapiens | Q96R06 | 32296183 | |
|
Intra
|
KRT3 | P12035 | SPAG5 | Homo sapiens | Q96R06 | 32296183 | |
|
Intra
|
KRT3 | P12035 | SPAG5 | Homo sapiens | Q96R06 | 32296183 | |
|
Intra
|
KRT3 | P12035 | OIP5 | Homo sapiens | O43482 | 32296183 | |
|
Intra
|
KRT3 | P12035 | OIP5 | Homo sapiens | O43482 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT14 | Homo sapiens | P02533 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT14 | Homo sapiens | P02533 | 32296183 | |
|
Intra
|
KRT3 | P12035 | TRIM27 | Homo sapiens | P14373 | 32296183 | |
|
Intra
|
KRT3 | P12035 | TRIM27 | Homo sapiens | P14373 | 32296183 | |
|
Intra
|
KRT3 | P12035 | TRIM27 | Homo sapiens | P14373 | 32296183 | |
|
Intra
|
KRT3 | P12035 | HGS | Homo sapiens | O14964 | 32296183 | |
|
Intra
|
KRT3 | P12035 | HGS | Homo sapiens | O14964 | 32296183 | |
|
Intra
|
KRT3 | P12035 | LURAP1 | Homo sapiens | Q96LR2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | LURAP1 | Homo sapiens | Q96LR2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | LURAP1 | Homo sapiens | Q96LR2 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT20 | Homo sapiens | P35900 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT19 | Homo sapiens | P08727 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT19 | Homo sapiens | P08727 | 32296183 | |
|
Intra
|
KRT3 | P12035 | ZNF426 | Homo sapiens | Q9BUY5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | ZNF426 | Homo sapiens | Q9BUY5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | ZNF426 | Homo sapiens | Q9BUY5 | 32296183 | |
|
Intra
|
KRT3 | P12035 | DEUP1 | Homo sapiens | Q05D60 | 32296183 | |
|
Intra
|
KRT3 | P12035 | DEUP1 | Homo sapiens | Q05D60 | 32296183 | |
|
Intra
|
KRT3 | P12035 | DEUP1 | Homo sapiens | Q05D60 | 32296183 | |
|
Intra
|
KRT3 | P12035 | CCDC197 | Homo sapiens | Q8NCU1 | 32296183 | |
|
Intra
|
KRT3 | P12035 | CCDC197 | Homo sapiens | Q8NCU1 | 32296183 | |
|
Intra
|
KRT3 | P12035 | CCDC197 | Homo sapiens | Q8NCU1 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
KRT3 | P12035 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
KRT3 | P12035 | PLEKHG4 | Homo sapiens | Q58EX7 | 32296183 | |
|
Intra
|
KRT3 | P12035 | PLEKHG4 | Homo sapiens | Q58EX7 | 32296183 | |
|
Intra
|
KRT3 | P12035 | PLEKHG4 | Homo sapiens | Q58EX7 | 32296183 | |
|
Intra
|
KRT3 | P12035 | BPIFA1 | Homo sapiens | Q9NP55 | 32296183 | |
|
Intra
|
KRT3 | P12035 | BPIFA1 | Homo sapiens | Q9NP55 | 32296183 | |
|
Intra
|
KRT3 | P12035 | BPIFA1 | Homo sapiens | Q9NP55 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Corneal Dystrophy, Meesmann, 2 |
|
|
| Corneal Dystrophy, Meesmann, 1 |
|
|
| Corneal Dystrophy |
|
|
| Corneal Disease |
|
|
| Keratoconus |
|
|
| Cicatricial Entropion |
|
|
| Astigmatism |
|
|
| Corneal Endothelial Dystrophy |
|
|
| Epithelial And Subepithelial Dystrophy |
|
|
| Recurrent Corneal Erosion |
|
|
| Corneal Dystrophy, Lisch Epithelial |
|
|
| Corneal Deposit |
|
|
| Granular Corneal Dystrophy |
|
|
| Hymenolepiasis |
|
|
| Filamentary Keratitis |
|
|
| Corneal Dystrophy, Thiel-Behnke Type |
|
|
| Pseudopterygium |
|
|
| Corneal Dystrophy, Reis-Bucklers Type |
|
|
| Anterior Scleritis |
|
|
| Punctate Epithelial Keratoconjunctivitis |
|
|
| Keratopathy |
|
|
| Corneal Dystrophy, Avellino Type |
|
|
| Corneal Dystrophy, Gelatinous Drop-Like |
|
|
| Cicatricial Pemphigoid |
|
|
| Macular Dystrophy, Corneal |
|
|
| Epithelial Basement Membrane Dystrophy |
|
|
| Plica Syndrome |
|
|
| Severe Cutaneous Adverse Reaction |
|
|
| Schnyder Corneal Dystrophy |
|
|
| Congenital Disorder Of Glycosylation, Type Iic |
|
|
| Deep Keratitis |
|
|
| Interstitial Keratitis |
|
|
| Entropion |
|
|
| Epithelial-Stromal Tgfbi Dystrophy |
|
|
| Orbital Granuloma |
|
|
| Corneal Degeneration |
|
|
| Corneal Ulcer |
|
|
| Aniridia 1 |
|
|
| Cardiac Valvular Dysplasia, X-Linked |
|
|
| Irregular Astigmatism |
|
|
| Corneal Dystrophy, Posterior Polymorphous, 1 |
|
|
| Iris Disease |
|
|
| Corneal Dystrophy, Subepithelial Mucinous |
|
|
| Corneal Edema |
|
|
| Meibomian Cyst |
|
|
| Hepatic Infarction |
|
|
| Conjunctival Squamous Cell Carcinoma |
|
|
| Stromal Dystrophy |
|
|
| Keratitis, Hereditary |
|
|
| Keratosis Follicularis Spinulosa Decalvans |
|
|
| Tyrosinemia, Type Ii |
|
|
| Fuchs' Endothelial Dystrophy |
|
|
| Breast Disease |
|
|
| Eye Disease |
|
|