PAX5 - paired box 5 Gene

Also Known as ALL3; BSAP; PAX-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5079

About PAX5

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:36,833,269-37,034,268 (from NCBI)

This gene has 18 transcripts (splice variants), 199 orthologues, 50 paralogues and is associated with 96 phenotypes. Biased expression in lymph node (RPKM 16.7), spleen (RPKM 9.5) and 3 other tissues.

Summary

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

PAX5 Products (11)

mRNA Protein Name
NM_001280547.2 NP_001267476.1 paired box protein Pax-5 isoform 2
NM_001280548.2 NP_001267477.1 paired box protein Pax-5 isoform 3
NM_001280549.2 NP_001267478.1 paired box protein Pax-5 isoform 4
NM_001280550.2 NP_001267479.1 paired box protein Pax-5 isoform 5
NM_001280551.2 NP_001267480.1 paired box protein Pax-5 isoform 6
NM_001280552.2 NP_001267481.1 paired box protein Pax-5 isoform 7
NM_001280553.2 NP_001267482.1 paired box protein Pax-5 isoform 8
NM_001280554.2 NP_001267483.1 paired box protein Pax-5 isoform 9
NM_001280555.2 NP_001267484.1 paired box protein Pax-5 isoform 10
NM_001280556.2 NP_001267485.1 paired box protein Pax-5 isoform 11
NM_016734.3 NP_057953.1 paired box protein Pax-5 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
24735925 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAX5 Protein Structure

PAX

PAX: 'Paired box' domain (16 - 140)

Pax2_C

Pax2_C: Paired-box protein 2 C terminal (282 - 390)

  • 0
  • 100
  • 200
  • 300
  • 391 a.a.
Protein Preferred Names Protein Names

paired box protein Pax-5

  • B-cell lineage specific activator

PAX5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PAX5 Q02548 PNMA5 Homo sapiens Q96PV4
Validated Y2H
32296183
Intra
PAX5 Q02548 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
PAX5 Q02548 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
PAX5 Q02548 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
PAX5 Q02548 GRHL2 Homo sapiens Q6ISB3
Validated Y2H
32296183
Intra
PAX5 Q02548 NEIL2 Homo sapiens Q969S2
Validated Y2H
32296183
Intra
PAX5 Q02548 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra
PAX5 Q02548 SEC14L4 Homo sapiens Q9UDX3
Validated Y2H
32296183
Intra
PAX5 Q02548 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
PAX5 Q02548 TLK2 Homo sapiens Q86UE8
Validated Y2H
32296183
Intra
PAX5 Q02548 GNG13 Homo sapiens Q9P2W3
Validated Y2H
32296183
Intra
PAX5 Q02548 ACOT12 Homo sapiens Q8WYK0
Validated Y2H
32296183
Intra
PAX5 Q02548 NFYC Homo sapiens Q13952-2
Validated Y2H
32296183
Intra
PAX5 Q02548 CXorf38 Homo sapiens Q8TB03
Validated Y2H
32296183
Intra
PAX5 Q02548 LARP4 Homo sapiens Q6P4E2
Validated Y2H
32296183
Intra
PAX5 Q02548 ZMYM5 Homo sapiens Q9UJ78-2
Validated Y2H
32296183
Intra
PAX5 Q02548 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Prey Pooling
32296183
Intra
PAX5 Q02548 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Array
32296183
Intra
PAX5 Q02548 UBXN2B Homo sapiens Q14CS0
Validated Y2H
32296183
Intra
PAX5 Q02548 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Intra
PAX5 Q02548 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
32296183
Intra
PAX5 Q02548 Q03164-PRO_0000390949 Homo sapiens Q03164-PRO_0000390949
Anti Bait CoIP
24735925
Intra
PAX5 Q02548 STAC Homo sapiens Q99469
Validated Y2H
32296183
Intra
PAX5 Q02548 NGLY1 Homo sapiens Q96IV0
Validated Y2H
32296183
Intra
PAX5 Q02548 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
32296183
Intra
PAX5 Q02548 HGS Homo sapiens O14964
Y2H Prey Pooling
32296183
Intra
PAX5 Q02548 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
PAX5 Q02548 SAE1 Homo sapiens Q9UBE0
Validated Y2H
32296183
Intra
PAX5 Q02548 LDLRAP1 Homo sapiens Q5SW96
Validated Y2H
32296183
Intra
PAX5 Q02548 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

PAX5 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82852 PAX5 Antibody (YA2597) WB, IHC-P, ICC/IF, FC Human, Mouse
HY-P85887 PAX5 Antibody (YA5579) IHC-P, WB, ICC/IF, ELISA Human, Mouse, Rat
HY-P86020 PAX5 Antibody (YA5712) IHC-P, ELISA Human, Mouse, Rat
HY-P86357 MEK-4 Antibody (YA6049) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Leukemia, Acute Lymphoblastic 3

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3

  • ALL3

  • Precursor B-Cell Acute Lymphoblastic Leukemia

  • B-All

  • Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor B-Cell Acute Lymphocytic Leukemia

  • Precursor B-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

  • Burkitt Lymphoma

  • Precursor B-Cell Lymphoblastic Leukemia
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Lymphoplasmacytic Lymphoma

  • Waldenstrom Macroglobulinemia

  • Malignant Lymphoma - Lymphoplasmacytic

  • Waldenström Macroglobulinaemia

  • Waldenström Macroglobulinaemia Without Mention Of Remission

  • Idiopathic Macroglobulinaemia

  • Primary Macroglobulinaemia
Splenic Marginal Zone Lymphoma

  • Smzl

  • Splenic Marginal Zone B-Cell Lymphoma
B-Lymphoblastic Leukemia/Lymphoma

  • B Lymphoblastic Leukemia/Lymphoma

  • B-All

  • Precursor B Lymphoblastic Lymphoma/Leukemia

  • C-All

  • Lymphoblastic Lymphoma, Nos

  • Common Precursor B All

  • Lymphoblastic B-Cell Lymphoma

  • Pro-B All

  • B-Precursor Lymphoma

  • Lbl - [Lymphoblastic Lymphoma]
Anaplastic Large Cell Lymphoma

  • Alcl

  • Cd30 Positive Anaplastic Large Cell Lymphoma

  • Ki-1 Positive Anaplastic Large Cell Lymphoma

  • Primary Systemic Alcl

  • Sacl

  • Ki-1+ Anaplastic Large Cell Lymphoma
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Acute Leukemia

  • Stem Cell Leukaemia

  • Stem Cell Leukemia

  • Acute Leukemias

  • Acute Undifferentiated Leukemia

  • Undifferentiated Leukemia

  • Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

  • Blast Cell Leukaemia

  • Blast Leukaemia

  • Blastic Leukaemia

  • Undifferentiated Leukaemia
Merkel Cell Carcinoma

  • Trabecular Adenocarcinoma

  • Cutaneous Neuroendocrine Carcinoma

  • Trabecular Carcinoma

  • Carcinoma, Merkel Cell

  • Merkel Cell Cancer

  • Merkle Tumors

  • Mcc

  • Carcinoma Merkel Cell
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Waldenstroem'S Macroglobulinemia

  • Waldenstrom Macroglobulinemia

  • Macroglobulinemia Of Waldenstrom

  • Waldenström Macroglobulinemia

  • Lymphoplasmacytic Lymphoma With Igm Gammopathy

  • Lymphoplasmacytic Lymphoma

  • Waldenstrom'S Macroglobulinaemia

  • Waldenstrom'S Syndrome

  • Waldenstrom'S Macroglobulinemia

  • Wm

  • Waldenström'S Macroglobulinemia

  • Malignant Lymphoma - Lymphoplasmacytic
B-Cell Lymphoma

  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos
Submandibular Adenitis

  • Submandibular Lymphadenitis
Neuroendocrine Carcinoma

  • Neuroendocrine Cancer

  • Carcinoma Neuroendocrine

  • Carcinoma, Neuroendocrine
Reticulosarcoma

  • Histiocytic Lymphoma

  • Large-Cell Lymphomas

  • Lymphoma, Large-Cell

  • Lymphoma Large Cell

  • Diffuse Large B-Cell Lymphoma

  • Histiocytic Sarcoma
Gray Zone Lymphoma

  • B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Lymphoma, Hodgkin, Classic

  • Hodgkin Lymphoma

  • Hodgkin Disease

  • Hodgkin'S Lymphoma

  • Hodgkins Lymphoma

  • Classic Hodgkin Lymphoma

  • CHL

  • Hodgkin Lymphoma, Susceptibility To

  • Hl

  • Hodgkin'S Sarcoma

  • Stage I Subdiaphragmatic Hodgkin Lymphoma

  • Stage Ii Subdiaphragmatic Hodgkin Lymphoma

  • Lymphoma, Hodgkin'S

  • Classic Hodgkin Disease

  • Hodgkin'S Disease

  • Lymphoma, Hodgkin, Susceptibility To

  • Hodgkin'S Disease Of Intrapelvic Lymph Nodes

  • Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

  • Malignant Lymphogranuloma

  • Malignant Lymphogranulomatosis

  • Malignant Hodgkin Lymphoma

  • Classical Hodgkin Lymphoma, Type Not Specified
Lymphoma, Non-Hodgkin, Familial

  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma
Macroglobulinemia

  • Primary Macroglobulinemia

  • Waldenstrom Macroglobulinemia
Hodgkin'S Lymphoma, Lymphocytic Depletion

  • Hodgkin Lymphoma, Lymphocyte Depletion

  • Hodgkin'S Disease, Lymphocytic Depletion

  • Hodgkin'S Lymphocytic Depletion Of Unspecified Site

  • Lymphocyte-Depleted Classical Hodgkin Lymphoma

  • Classic Hodgkin Lymphoma, Lymphocyte-Depleted Type

  • Hodgkin Disease, Lymphocytic Depletion

  • Hodgkin Lymphocytic Depletion
Selective Igg Deficiency Disease

  • Igg Deficiency

  • Immunoglobin G Subclass Deficiency

  • Selective Deficiency Of Igg

  • Selective Igg Immunodeficiency

  • Selective Immunoglobulin G Deficiency

  • Selective Immunoglobulin G Subclass Deficiency
Mediastinal Gray Zone Lymphoma

  • Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Mediastinal Malignant Lymphoma

  • Lymphoma Of Mediastinum

  • Mediastinal Lymphoma
Plasmacytoma

  • Solitary Plasmacytoma

  • Solitary Myeloma

  • Myeloma - Solitary

  • Myeloma, Solitary

  • Plasmacytoma - Category

  • Solitary Osseous Plasmacytoma

  • Solitary Plasmacytoma Without Mention Of Remission

  • Localised Malignant Plasma Cell Tumour Nos

  • Plasmacytoma Nos
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1

  • B-All With Bcr-Abl1

  • B-Lymphoblastic Leukemia/Lymphoma With T(9

  • 22)(Q34.1

  • Q11.2)

  • Bcr-Abl1

  • B Lymphoblastic Leukemia/Lymphoma With T(9

  • 22)(Q34.1

  • Q11.2)

  • Bcr-Abl1
Lymphoblastic Lymphoma

  • Lymphoma, Lymphoblastic

  • Lymphoma Lymphoblastic

  • Precursor Cell Lymphoblastic Lymphoma

  • Precursor Cell Lymphoblastic Leukemia Lymphoma
Hodgkin'S Lymphoma, Nodular Sclerosis

  • Classical Hodgkin Lymphoma, Nodular Sclerosis

  • Classic Hodgkin Lymphoma, Nodular Sclerosis Type

  • Nodular Sclerosis Hodgkin Lymphoma

  • Hodgkin'S Disease, Nodular Sclerosis

  • Hodgkin Disease, Nodular Sclerosis

  • Hodgkin Lymphoma, Nodular Sclerosis

  • Hodgkin Nodular Sclerosis
Tracheal Lymphoma

  • Lymphoma Of The Trachea

  • Lymphoma Of Trachea
Peripheral T-Cell Lymphoma

  • Lymphoma T-Cell Peripheral
Composite Lymphoma

  • Composite Hodgkin And Non-Hodgkin Lymphoma
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Plasmablastic Lymphoma

  • Pbl

  • Immunoblastic Large-Cell Lymphoma
Follicular Lymphoma

  • Lymphoma, Follicular

  • Lymphoma Follicular

  • Brill-Symmers' Disease

  • Large Cell Follicular Non-Hodgkin Lymphoma

  • Diffuse Follicle Centre Lymphoma

  • Diffuse Follicular Lymphoma Nos

  • Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

  • Follicular Large Cell Cleaved Or Noncleaved Lymphoma

  • Large Cell Follicular Noncleaved Lymphoma

  • Follicular Lymphoma With Or Without Diffuse Areas

  • Histiocytic Follicular Lymphoma

  • Histiocytic Nodular Lymphoma

  • Histiocytic Nodular Malignant Lymphoma

  • Large Cell Follicular Lymphoma

  • Large Cell Noncleaved Follicular Lymphoma

  • Large Cell Noncleaved Follicular Malignant Lymphoma

  • Nodular Reticulum Cell Sarcoma

  • Noncleaved Follicular Lymphoma
Hematologic Cancer

  • Hematologic Neoplasm

  • Hematologic Neoplasms

  • Hematologic Malignancies

  • Blood Cancer

  • Hematologic Malignancy

  • Hematological Tumors

  • Hematopoietic And Lymphoid System Tumor

  • Hematopoietic Cancer

  • Hematopoietic Neoplasm

  • Hematopoietic Tumors

  • Malignant Hematopoietic Neoplasm

  • Liquid Tumor

  • Hematopoietic Neoplasms
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  • Cll/Sll

  • B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  • Icdo:9823/3

  • Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

  • Small Cell B-Cell Lymphoma
Lung Lymphoma

  • Pulmonary Lymphoma

  • Lymphoma Of Lung

  • Primary Lung Lymphoma
Monoclonal Paraproteinemia

  • Monoclonal Paraproteinaemia
B-Lymphoblastic Leukemia/Lymphoma With Iamp21

  • B-All With Iamp21

  • Intrachromosomal Amplification Of Chromosome 21
Primary Hyperparathyroidism

  • Familial Primary Hyperparathyroidism

  • Hyperparathyroidism, Primary

  • Hyperparathyroidism Primary

  • Hypocalciuric Hypercalcemia, Familial, Type 1

  • Familial Benign Hypercalcemia

  • Familial Hyperparathyroidism

  • Parathyroid Enlargement
Extramedullary Plasmacytoma

  • Extraosseous Plasmacytoma

  • Plasmacytoma, Extramedullary
Bone Lymphoma

  • Lymphoma Of Bone

  • Lymphoma Of The Bone
Breast Lymphoma

  • Lymphoma Of Breast

  • Lymphoma Of The Breast

  • Malignant Lymphoma Of Breast
Gamma Heavy Chain Disease

  • Franklin Disease

  • Franklin'S Disease

  • Gamma Heavy Chain Deposition Disease

  • Igg Heavy Chain Disease

  • Gamma-Heavy Chain Disease

  • Gamma-Hcd

  • Gamma-Chain Disease
Multicentric Castleman Disease

  • Mcd

  • Multicentric Giant Lymph Node Hyperplasia

  • Plasmablastic Multicentric Castleman Disease

  • Pmcd

  • Idiopathic Multicentric Castleman Disease

  • Multi-Centric Castleman'S Disease

  • Idiopathic Multicentric Castleman'S Disease

  • Multicentric Plasma Cell Variant Of Castleman'S Disease

  • Hhv-8-Negative Multicentric Castleman Disease

  • Human Herpesvirus-8-Negative Multicentric Castleman Disease
Marginal Zone B-Cell Lymphoma

  • Marginal Zone Lymphoma

  • Mzl

  • Mucosa-Associated Lymphoid Tissue Lymphoma
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Histiocytic And Dendritic Cell Cancer

  • Histiocytic And Dendritic Cell
Adult Acute Lymphocytic Leukemia

  • Adult Acute Lymphoid Leukemia

  • Adult All
Mediastinal Cancer

  • Mediastinal Neoplasms

  • Mediastinal Tumor

  • Mediastinum Cancer

  • Neoplasm Of Mediastinum

  • Tumour Of Mediastinum

  • Malignant Tumor Of Mediastinum
Mature B-Cell Neoplasm

  • Mature B-Cell Lymphocytic Neoplasm

  • Neoplasm Of Mature B-Cells

  • Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Richter'S Syndrome

  • Richter Syndrome

  • Richter Transformation
Adult Lymphoma
Spleen Cancer

  • Spleen Neoplasm

  • Splenic Neoplasm

  • Splenic Neoplasms

  • Malignant Splenic Tumor

  • Malignant Tumour Of Spleen

  • Tumor Of Spleen

  • Malignant Neoplasm Of Spleen
Central Nervous System Hematologic Cancer

  • Cns Hematopoietic Tumor

  • Hematopoietic Neoplasm Of Central Nervous System

  • Central Nervous System Hematopoietic Neoplasm
Childhood Lymphoma

  • Pediatric Lymphoma
Angioimmunoblastic T-Cell Lymphoma

  • Immunoblastic Lymphadenopathy

  • Lymphogranulomatosis X

  • T-Cell Lymphoma, Aild Type

  • Aitl

  • Ailt

  • Angioimmunoblastic Lymphadenopathy

  • Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia]

  • Angioimmunoblastic Lymphoma
Acute Biphenotypic Leukemia

  • Mixed Phenotype Acute Leukemia

  • Acute Leukemia Of Ambiguous Lineage

  • Acute Undifferentiated Leukemia

  • Acute Leukemia Of Indeterminate Lineage

  • Hybrid Acute Leukemia

  • Mixed Lineage Acute Leukemia

  • All With Myeloid Markers

  • Aml With Lymphoid Markers

  • Acute Leukemia Of Undetermined Lineage

  • Bal

  • Biphenotypic Acute Leukemia

  • Undifferentiated Acute Leukemia

  • Mpal

  • Acute Myeloid Leukemia, Minimal Differentiation, Fab M0

  • Leukemia, Biphenotypic, Acute
Central Nervous System Lymphoma

  • Microglioma

  • Primary Cns Lymphoma

  • Cns Lymphoma

  • Primary Central Nervous System Lymphoma
Rhabdomyosarcoma
Appendix Lymphoma

  • Appendiceal Lymphoma
Chronic Kidney Disease

  • Chronic Renal Disease

  • Chronic Kidney Failure

  • Ckd

  • Chronic Renal Failure

  • Kidney Failure, Chronic

  • Chronic Renal Failure Syndrome

  • Crf

  • Renal Failure - Chronic

  • Renal Failure Chronic

  • Chronic Kidney Diseases

  • Chronic Kidney Disease Stage 5

  • Ckd - [Chronic Kidney Disease]

  • Crf - [Chronic Renal Failure]

  • Chronic Kidney Impairment

  • Chronic Renal Impairment

  • Chronic Kidney Shutdown

  • Chronic Hypoxic Kidney Failure

  • Chronic Kidney Collapse

  • Chronic Renal Insufficiency

  • Chronic Kidney Toxaemia

  • Chronic Kidney Hypofunction

  • Chronic Renal Suppression

  • Chronic Renal Failure, Stage 5

  • Ckd - [Chronic Kidney Disease] Stage 5

  • End Stage Kidney Failure

  • End Stage Renal Failure

  • End Stage Kidney Disease

  • End Stage Renal Disease

  • End Stage Chronic Renal Failure

  • Esrf - [End Stage Renal Failure]

  • Esrd - [End Stage Renal Diseases]

  • Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Prion Disease

  • Spongiform Encephalopathy

  • Transmissible Spongiform Encephalopathies

  • Prion Diseases

  • Prion Disease Pathway

  • Transmissible Spongiform Encephalopathy

  • Prion Induced Disorder

  • Prion Protein Disease

  • Inherited Human Transmissible Spongiform Encephalopathies

  • Prion Protein Diseases

  • Prion-Associated Disorders

  • Prion-Induced Disorders

  • Transmissible Dementias

  • Tses

  • Human Prion Disease

  • Tse

  • Encephalopathy, Transmissible Spongiform

  • Prion Disease, Susceptibility To

  • Spongiform Encephalopathies

  • Human Transmissible Spongiform Encephalopathies, Inherited
Paranasal Sinus Lymphoma

  • Lymphoma Of Accessory Sinus

  • Lymphoma Of Paranasal Sinus
Ureteral Lymphoma

  • Lymphoma Of Ureter

  • Ureter Lymphoma
Mantle Cell Lymphoma

  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma
Lymphoma, Mucosa-Associated Lymphoid Type

  • Malt Lymphoma

  • Gastric Lymphoma, Primary

  • Lymphoma, Malt, Somatic

  • Mucosa-Associated Lymphoid Tissue Lymphoma

  • Extranodal Marginal Zone B-Cell Lymphoma

  • MALTOMA

  • Marginal Zone B-Cell Lymphoma

  • Mucosa-Associated Lymphatic Tissue Lymphoma

  • Primary Gastric Lymphoma

  • Gastric Lymphoma

  • Familial Primary Gastric Lymphoma
Primary Central Nervous System Lymphoma

  • Pcnsl

  • Primary Cns Lymphoma

  • Primary Brain Lymphoma

  • Primary Lymphoma, Cns

  • Primary Cerebral Lymphoma
Mature T-Cell And Nk-Cell Lymphoma

  • Mature T-Cell And Natural Killer Cell Lymphoma

  • Nk-T Cell Lymphoma
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Renal Pelvis Transitional Cell Carcinoma

  • Urothelial Cell Carcinoma Of Renal Pelvis

  • Renal Pelvis Urothelial Carcinoma

  • Transitional Cell Carcinoma Of Renal Pelvis
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Plasma Cell Neoplasm

  • Plasma Cell Dyscrasia

  • Paraproteinemias

  • Plasma Cell Tumour

  • Plasmacytic Tumor

  • Multiple Myeloma

  • Plasmacytoma

  • Plasma Cell Tumours

  • Plasma Cells Dyscrasia
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10092 PAX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174558 Human PAX5 mRNA / Unkown
HY-RS20318 Pax5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26826 Pax5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PAX5 RGD RGD:1565236
Macaca mulatta PAX5 VGNC VGNC:75764
Felis catus PAX5 VGNC VGNC:68700
Bos taurus PAX5 VGNC VGNC:54466
Canis familiaris PAX5 VGNC VGNC:44278
Mus musculus PAX5 MGD MGI:97489
Others PAX5 NCBI