PLA2G10 - phospholipase A2 group X Gene

Also Known as SPLA2; GXPLA2; GXSPLA2; sPLA2-X

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8399

About PLA2G10

Cytogenetic location: 16p13.12-p13.11 Genomic coordinates (GRCh38): 16:14,672,548-14,701,850 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 225 orthologues and 8 paralogues. Biased expression in stomach (RPKM 10.4), colon (RPKM 7.1) and 6 other tissues.

Summary

This gene encodes a member of the Phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane Phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast Cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

PLA2G10 Products (1)

mRNA	Protein	Name
NM_003561.3	NP_003552.1	group 10 secretory phospholipase A2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IDA IDA: Inferred from direct assay	16962371	GOA
enables calcium-dependent phospholipase A2 activity	IDA IDA: Inferred from direct assay	12021277	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	15927955	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	16146426	GOA
involved in low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	12021277	GOA
acts upstream of or within lysophospholipid transport	IDA IDA: Inferred from direct assay	15927955	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20844270	GOA
involved in phosphatidic acid metabolic process	IDA IDA: Inferred from direct assay	12359733	GOA
involved in phosphatidylcholine catabolic process	IDA IDA: Inferred from direct assay	12021277	GOA
involved in phosphatidylcholine metabolic process	IDA IDA: Inferred from direct assay	12359733	GOA
involved in phosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	12359733	GOA
involved in phosphatidylglycerol metabolic process	IDA IDA: Inferred from direct assay	12359733	GOA
involved in phosphatidylserine metabolic process	IDA IDA: Inferred from direct assay	12359733	GOA
involved in platelet activating factor catabolic process	IDA IDA: Inferred from direct assay	16962371	GOA
involved in positive regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	18511424	GOA
involved in positive regulation of prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	18511424	GOA
involved in positive regulation of protein metabolic process	IMP IMP: Inferred from mutant phenotype	18511424	GOA
involved in regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	18511424	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular space	IDA IDA: Inferred from direct assay	21805676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G10 Protein Structure

Phospholip_A2_1

0
100
165 a.a.

Protein Preferred Names	Protein Names
group 10 secretory phospholipase A2	group X secretory phospholipase A2

PLA2G10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PLA2G10	O15496	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	PLA2G10	O15496	LCE2A	Homo sapiens	Q5TA79	Validated Y2H	32296183
Intra	PLA2G10	O15496	LCE2D	Homo sapiens	Q5TA82	Validated Y2H	32296183
Intra	PLA2G10	O15496	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	PLA2G10	O15496	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	PLA2G10	O15496	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	PLA2G10	O15496	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	PLA2G10	O15496	LCE2B	Homo sapiens	O14633	MAPPIT	32296183
Intra	PLA2G10	O15496	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	PLA2G10	O15496	LCE1A	Homo sapiens	Q5T7P2	Y2H Prey Pooling	32296183
Intra	PLA2G10	O15496	LCE1A	Homo sapiens	Q5T7P2	Y2H Array	32296183
Intra	PLA2G10	O15496	LCE1A	Homo sapiens	Q5T7P2	Validated Y2H	32296183
Intra	PLA2G10	O15496	GNE	Homo sapiens	Q9Y223-2	Validated Y2H	32296183
Intra	PLA2G10	O15496	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	PLA2G10	O15496	NOXA1	Homo sapiens	Q86UR1-2	Validated Y2H	32296183
Intra	PLA2G10	O15496	POU4F3	Homo sapiens	Q15319	Validated Y2H	32296183
Intra	PLA2G10	O15496	HSF4	Homo sapiens	Q9ULV5-2	Validated Y2H	32296183
Intra	PLA2G10	O15496	GATA5	Homo sapiens	Q9BWX5	Validated Y2H	32296183
Intra	PLA2G10	O15496	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	PLA2G10	O15496	LCE1C	Homo sapiens	Q5T751	Validated Y2H	32296183
Intra	PLA2G10	O15496	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	PLA2G10	O15496	HOXC8	Homo sapiens	P31273	Validated Y2H	32296183
Intra	PLA2G10	O15496	FOXH1	Homo sapiens	O75593	Validated Y2H	32296183
Intra	PLA2G10	O15496	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183
Intra	PLA2G10	O15496	TBX6	Homo sapiens	O95947	Validated Y2H	32296183
Intra	PLA2G10	O15496	HR	Homo sapiens	O43593	Validated Y2H	32296183
Intra	PLA2G10	O15496	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	PLA2G10	O15496	MAL	Homo sapiens	P21145	Validated Y2H	32296183
Intra	PLA2G10	O15496	TLX3	Homo sapiens	O43711	Validated Y2H	32296183
Intra	PLA2G10	O15496	KRTAP26-1	Homo sapiens	Q6PEX3	Validated Y2H	32296183
Intra	PLA2G10	O15496	ROR2	Homo sapiens	Q01974	Validated Y2H	32296183
Intra	PLA2G10	O15496	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	PLA2G10	O15496	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	PLA2G10	O15496	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	PLA2G10	O15496	AGXT	Homo sapiens	P21549	Validated Y2H	32296183
Intra	PLA2G10	O15496	OTX1	Homo sapiens	P32242	Validated Y2H	32296183
Intra	PLA2G10	O15496	NTAQ1	Homo sapiens	Q96HA8	Anti Tag CoIP	33961781
Intra	PLA2G10	O15496	NTAQ1	Homo sapiens	Q96HA8	Anti Tag CoIP	28514442
Intra	PLA2G10	O15496	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	PLA2G10	O15496	ZC3H10	Homo sapiens	Q96K80	Validated Y2H	32296183
Intra	PLA2G10	O15496	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	PLA2G10	O15496	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	PLA2G10	O15496	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	PLA2G10	O15496	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	PLA2G10	O15496	BAG3	Homo sapiens	O95817	Validated Y2H	32296183
Intra	PLA2G10	O15496	PITX1	Homo sapiens	P78337	Validated Y2H	32296183
Intra	PLA2G10	O15496	STK16	Homo sapiens	O75716	Validated Y2H	32296183
Intra	PLA2G10	O15496	SNRPC	Homo sapiens	P09234	Validated Y2H	32296183
Intra	PLA2G10	O15496	ATXN1	Homo sapiens	P54253	Validated Y2H	32296183
Intra	PLA2G10	O15496	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	32296183
Intra	PLA2G10	O15496	MAPKBP1	Homo sapiens	O60336	Validated Y2H	32296183
Intra	PLA2G10	O15496	ARID5A	Homo sapiens	Q03989	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Exercise-Induced Bronchoconstriction	Exercise-Induced Asthma Asthma Exercise-Induced
Parkinson Disease 14, Autosomal Recessive	PARK14 Dystonia-Parkinsonism, Adult-Onset Autosomal Recessive Parkinson Disease 14 Parkinson'S Disease 14 Dystonia-Parkinsonism Adult-Onset Adult-Onset Dystonia-Parkinsonism Dystonia-Parkinsonism, Paisan-Ruiz Type Pla2g6-Related Dystonia-Parkinsonism Parkinson Disease 14 Autosomal Recessive Parkinson'S Disease 14 Nbia/Dyt/Park-Pla2g6 Dystonia-Parkinsonism Paisan-Ruiz Type Parkinson Disease 14 Autosomal Recessive Parkinson Disease, Type 14
Meconium Aspiration Syndrome	Neonatal Aspiration Of Meconium Meconium Aspiration Mas Meconium Aspiration Syndrome Of Newborn Meconium Inhalation Mas - [Meconium Aspiration Syndrome] Meconium Aspiration Nos Meconium Aspiration Syndrome Nos Meconium Pneumonitis Meconium Stained Liqueur Aspiration
Acute Chest Syndrome	Acute Chest Syndrome In Sickle Cell Disease
Inhalation Anthrax	Pulmonary Anthrax Respiratory Anthrax Inhalational Anthrax Wool-Sorters' Disease Woolsorters' Disease Inhalation Anthrax Disease Respiratory Anthrax Disease
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10616	PLA2G10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLA2G10	RGD	RGD:61935
Canis familiaris	PLA2G10	VGNC	VGNC:54056
Mus musculus	PLA2G10	MGD	MGI:1347522
Felis catus	PLA2G10	VGNC	VGNC:68878
Others	PLA2G10	NCBI