ICT5040
ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells.
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- CAS. Nr.: 215655-21-3
- Formel: C10H8F3N3OS
- Molecular Weight:275.25
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Biologische Aktivität
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CXCR4 3.8 μM (IC50) |
ICT5040 (1-100 μM; 0-4 d) dose-dependently inhibits CXCL12-induced proliferation and migration of U87-glioma cells[1].
ICT5040 reduces CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87-glioma cells
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Concentration:1 μM, 10 μM, 100 μM; with 100 ng/mL CXCL12
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Incubation Time:0, 1, 2, 3, and 4 days
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Result:Resulted reduction of CXCL12 induced proliferation and migration of U87 cells at day 3.
Chemical Information
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CAS. Nr. 215655-21-3
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Molecular Weight 275.25
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Formel C10H8F3N3OS
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SMILES
FC(C1=CC=C(C2=NN=C(SC)O2)C(C)=N1)(F)F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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