Idescarpin
Based on 1 Customer Validation
Idescarpin is a phenolic glycoside compound isolated from Idesia polycarpa and exhibits an extremely bitter taste. Idescarpin possesses significant anti-inflammatory, antioxidant, and potent anti-adipogenic activities. Idescarpin reduces melanin biosynthesis by inhibiting tyrosinase activity. Idescarpin is applicable to research on obesity and type 2 diabetes, as well as related studies in food and cosmetics.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 93.0%
- CAS. Nr.: 188557-53-1
- Formel: C20H24O11
- Molecular Weight:440.40
-
Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PPAR-γ |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | IC50 |
23.2 μM
|
Inhibition of adipocyte differentiation in 3T3-L1 preadipocytes assessed by Oil Red O lipid staining quantification after 8-day incubation during differentiation.
Inhibition of adipocyte differentiation in 3T3-L1 preadipocytes assessed by Oil Red O lipid staining quantification after 8-day incubation during differentiation.
|
j.fbio.2025.106228 |
In Vitro
Idescarpin (25-50 μM; 8 days) significantly reduces lipid droplet formation and inhibits preadipocyte-to-adipocyte differentiation in mouse preadipocytes (3T3-L1)[2].
Idescarpin (25-50 μM; 4-8 days) significantly inhibits C/EBPα protein and mRNA expression in mouse preadipocytes (3T3-L1), downregulates the mRNA expression of adipogenesis-related genes (SREBP1c, SCD-1, FAS), but upregulates PPARγ protein and mRNA expression[2].
Idescarpin (2-10 μg/mL; 24 h) is a key substance in the anti-inflammatory activity of defatted Idesia polycarpa extract, showing a negative correlation with inflammatory mediators (NO, iNOS, TNF-α, IL-6, ROS) and a positive correlation with CAT activity in LPS (HY-D1056)-stimulated RAW 264.7 cells[1].
Idescarpin is predicted to activate 7 human bitter taste receptors (hTAS2R1, hTAS2R5, hTAS2R14, hTAS2R16, hTAS2R39, hTAS2R41, hTAS2R43), with activation probabilities ranging from 51.08% to 69.31%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:3T3-L1 preadipocytes undergoing differentiation
-
Concentration:25 μM; 50 μM
-
Incubation Time:4 days; 8 days
-
Result:Significantly increased the relative induction of PPARγ mRNA on days 4 and 8.
Dramatically suppressed the relative induction of C/EBPa mRNA on days 4 and 8.
Decreased mRNA levels of SREBP1c, SCD-1, and FAS at both concentrations on days 4 and 8.
Slightly reduced aP2 mRNA levels at both concentrations on days 4 and 8.
-
Cell Line:3T3-L1 preadipocytes undergoing differentiation
-
Concentration:25 μM; 50 μM
-
Incubation Time:4 days; 8 days
-
Result:Increased PPARγ protein levels on days 4 and 8 at 25 μM and 50 μM.
Decreased C/EBPa protein levels on days 4 and 8 at 25 μM and 50 μM.
Chemical Information
-
CAS. Nr. 188557-53-1
-
Appearance Solid
-
Molecular Weight 440.40
-
Formel C20H24O11
-
Color White to off-white
-
SMILES
O=C([C@]1(C(CCC=C1)=O)O)OCC(C=CC=C2O)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
-
Structure Classification
-
Initial Source
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Idescarpin Related Classifications
HY-N19582 Related Classifications
Powered by Bioz
Keywords
- Idescarpin
- 188557-53-1
- Endogenous Metabolite
- PPAR
- sterol regulatory element binding protein 1c
- fatty acid synthase
- CCAAT/enhancer binding protein α
- interleukin-6
- inducible nitric oxide synthase
- stearoyl-CoA desaturase 1
- RAW 264.7 cells
- peroxisome proliferator-activated receptor γ
- tumor necrosis factor-α
- 3T3-L1 preadipocytes
- Inhibitor
- inhibitor
- inhibit