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Art. -Nr.: HY-119764

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Ikarugamycin

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME).

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Reinheit: 99.9%
CAS. Nr.: 36531-78-9
Formel: C₂₉H₃₈N₂O₄
Molecular Weight:478.62

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ikarugamycin Chemical Structure

CAS. Nr.: 36531-78-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME)^[1].

IC₅₀ & Target

Clathrin-mediated endocytosis^[1]

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

Ikarugamycin has an IC₅₀ of 2.7 μM in H1299 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 36531-78-9
Appearance Solid
Molecular Weight 478.62
Formel C₂₉H₃₈N₂O₄
Color White to light yellow
SMILES

O=C(/C=C/[C@@H]1C[C@]2([C@@]([H])([C@H]1C/C=C\3)C=C[C@@]4([C@@]2(C[C@H]([C@H]4CC)C)[H])[H])[H])C5=C([C@@H](NC5=O)CCCNC3=O)O
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces species
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

J Extracell Vesicles

Cdc42 functions as a regulatory node for tumour-derived microvesicle biogenesis. [Abstract]

2021 Jan;10(3):e12051. PMID: 33473262
J Immunother Cancer

Anticancer effects of ikarugamycin and astemizole identified in a screen for stimulators of cellular immune responses. [Abstract]

2023 Jul;11(7):e006785. PMID: 37419511

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Elkin SR, et al. Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis. Traffic. 2016 Oct;17(10):1139-49. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Ikarugamycin

2 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Reinheit & Dokumentation
Verweise

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Ikarugamycin

Publications Citing Use of MedChemExpress (MCE) Ikarugamycin

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Ikarugamycin Related Classifications

HY-119764 Related Classifications