LY379268
Based on 1 publication(s) in Google Scholar
LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.84%
- CAS. Nr.: 191471-52-0
- Formel: C7H9NO5
- Molecular Weight:187.15
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) LY379268
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Biologische Aktivität
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hmGluR2 2.69 nM (EC50) |
hmGluR3 4.48 nM (EC50) |
hmGluR2 14.1 nM (Ki) |
hmGluR3 5.8 nM (Ki) |
Treatment of 9-weeks (9w) astrocytes with LY379268 (0.1 μM; 24-48 hours) results in an increase in mGlu3R and Nrf2 protein levels and SOD activity, and decreases mitochondrial ROS levels and apoptosis. mGlu3R activation in aged astrocytes also preventS hippocampal neuronal death induced by Aβ1-42 in co-culture assays. Activation of mGlu3R in aged astrocytes haS an anti-oxidant effect and protected hippocampal neurons against Aβ-induced neurotoxicity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In a model of mouse tail withdrawal to warm water, LY379268 (12 mg/kg; i.p.), given before a subcutaneous tail injection of capsaicin, reduces the subsequent neurogenic hyperalgesia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 191471-52-0
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Appearance Solid
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Molecular Weight 187.15
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Formel C7H9NO5
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Color White to off-white
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SMILES
O=C([C@]1(N)CO[C@@]2([H])[C@H](C(O)=O)[C@@]12[H])O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Res
2025 Mar;35(3):165-185. PMID: 39875551
Lösungsmittel & Löslichkeit
0.1 M NaOH : 200 mg/mL (1068.66 mM; ultrasonic and adjust pH to 8 with NaOH)
H2O : 2 mg/mL (10.69 mM; ultrasonic and adjust pH to 10 with NaOH)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (133.58 mM); Clear solution; Need ultrasonic
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. J A Monn, et al. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 1999 Mar 25;42(6):1027-40. [Content Brief]
[2]. E F Sharpe, et al. Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo. Br J Pharmacol. 2002 Mar;135(5):1255-62. [Content Brief]
[3]. Juan Turati, et al. Antioxidant and neuroprotective effects of mGlu3 receptor activation on astrocytes aged in vitro. Neurochem Int. 2020 Nov;140:104837. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 0.1 M NaOH | 1 mM | 5.3433 mL | 26.7164 mL | 53.4328 mL | 133.5820 mL |
| 5 mM | 1.0687 mL | 5.3433 mL | 10.6866 mL | 26.7164 mL | |
| 10 mM | 0.5343 mL | 2.6716 mL | 5.3433 mL | 13.3582 mL | |
| 0.1 M NaOH | 15 mM | 0.3562 mL | 1.7811 mL | 3.5622 mL | 8.9055 mL |
| 20 mM | 0.2672 mL | 1.3358 mL | 2.6716 mL | 6.6791 mL | |
| 25 mM | 0.2137 mL | 1.0687 mL | 2.1373 mL | 5.3433 mL | |
| 30 mM | 0.1781 mL | 0.8905 mL | 1.7811 mL | 4.4527 mL | |
| 40 mM | 0.1336 mL | 0.6679 mL | 1.3358 mL | 3.3395 mL | |
| 50 mM | 0.1069 mL | 0.5343 mL | 1.0687 mL | 2.6716 mL | |
| 60 mM | 0.0891 mL | 0.4453 mL | 0.8905 mL | 2.2264 mL | |
| 80 mM | 0.0668 mL | 0.3340 mL | 0.6679 mL | 1.6698 mL | |
| 100 mM | 0.0534 mL | 0.2672 mL | 0.5343 mL | 1.3358 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
LY379268 Related Classifications
HY-103558 Related Classifications
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