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Art. -Nr.: HY-183307

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mTOR-IN-29

mTOR-IN-29 (Compound 4k) is an mTOR inhibitor with a IC₅₀ of ~120 nM. mTOR-IN-29 inhibits mTOR kinase activity without affecting the phosphorylation of STAT3. mTOR-IN-29 acts as a cytotoxic agent against proliferating and senescent cells. mTOR-IN-29 can be used in studies related to glioblastoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₆H₁₅N₅S
Molecular Weight:309.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

mTOR-IN-29 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

STAT3

Alle mTOR Isoform-spezifische Produkte anzeigen :

Alle STAT Isoform-spezifische Produkte anzeigen :

In Vitro

mTOR-IN-29 (1-50 μM; 72 h) potently inhibits the growth of BJ, RPE-1 hTERT and U-251 MG cells, and its activity is almost equivalent to that of Torkinib (HY-10474)^[1].
mTOR-IN-29 (100 μM; 15 min pre-incubation) does not inhibit IL-6-induced STAT3 phosphorylation (Y705) in RPE-1 hTERT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

normal human dermal fibroblasts BJ, non-transformed telomerase-immortalized retinal pigment epithelial cells (RPE-1 hTERT), cancerous human glioblastoma cell line U-251 MG
Concentration:

1 μM, 10 μM, 50 μM
Incubation Time:

72 h
Result:

Suppressed growth of BJ, RPE-1 hTERT, and U-251 MG cells to a degree almost comparable to Torkinib.

Cell Proliferation Assay^[1]

Cell Line:

non-transformed telomerase-immortalized retinal pigment epithelial cells (RPE-1 hTERT), cancerous human glioblastoma cell lines U-251 MG and T98 G
Concentration:

0.05 μM, 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 50 μM
Incubation Time:

24 h
Result:

Showed growth suppression activity comparable to torkinib across all tested cell lines; T98 G cells appeared most sensitive (difference not statistically significant).
Exhibited crystal violet assay IC₅₀ values of 6.5 μM (RPE-1 hTERT), 7.5 μM (U-251 MG).
Exhibited resazurin assay IC₅₀ values of 7.7 μM (RPE-1 hTERT), 4.8 μM (U-251 MG).

Chemical Information

Molecular Weight 309.39
Formel C₁₆H₁₅N₅S
SMILES

NC1=C2C(N(C(C)C)N=C2C3=CC4=C(C=CC=C4)S3)=NC=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Oleksak P, et al. The structure-activity relationship study of torkinib derivatives as mTOR inhibitors with senolytic and STAT3 inhibitory activities. Bioorg Chem. 2026;176:109868. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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mTOR-IN-29

Alle mTOR Isoform-spezifische Produkte anzeigen

Alle STAT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

mTOR-IN-29 Related Classifications

HY-183307 Related Classifications