NR-11c
Based on 1 Customer Validation
NR-11c is a selective and potent p38α PROTAC degrader. NR-11c effectively degrades p38α in a variety of tumor cells. When administered intraperitoneally or intravenously to mice, NR-11c primarily acts in the liver. NR-11c can be used in cancer research. (Pink: p38α inhibitor 5 (HY-159799); Black: linker (HY-159800); Blue: VHL E3 ligase ligand (HY-112078)).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.75%
- Formel: C59H71BrF2N10O8S
- Molecular Weight:1198.22
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Help & FAQs
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Immunology/Inflammation Compound Library
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Anti-Breast Cancer Compound Library
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Anti-Lung Cancer Compound Library
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Anti-Cancer Metabolism Compound Library
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Neurodegenerative Disease-related Compound Library
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Anti-Ovarian Cancer Compound Library
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Anti-Rheumatic Arthritis Compound Library
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Lactylation Compound Library
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Alle PROTACs Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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p38α |
NR-11c (1-1000 nM; 24 h) effectively degrades p38α in a variety of tumor cell lines, among which in MDA-MB-231 cells, DC50 is 11.55 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS, MG63, SAOS-2, BBL358, MDA-MB-231 and T47D cells
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Concentration:1 μM
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Incubation Time:24 h
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Result:Significantly reduced the level of p38α.
Chemical Information
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Appearance Solid
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Molecular Weight 1198.22
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Formel C59H71BrF2N10O8S
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Color White to off-white
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SMILES
O=C([C@H]1N(C([C@@H](NC(CCCCCNC(CCCN2N=NC(CCCNC(C3=CC=C(C)C(N4C(C)=CC(OCC5=CC=C(F)C=C5F)=C(Br)C4=O)=C3)=O)=C2)=O)=O)C(C)(C)C)=O)C[C@@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (83.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8346 mL | 4.1729 mL | 8.3457 mL | 20.8643 mL |
| 5 mM | 0.1669 mL | 0.8346 mL | 1.6691 mL | 4.1729 mL | |
| 10 mM | 0.0835 mL | 0.4173 mL | 0.8346 mL | 2.0864 mL | |
| 15 mM | 0.0556 mL | 0.2782 mL | 0.5564 mL | 1.3910 mL | |
| 20 mM | 0.0417 mL | 0.2086 mL | 0.4173 mL | 1.0432 mL | |
| 25 mM | 0.0334 mL | 0.1669 mL | 0.3338 mL | 0.8346 mL | |
| 30 mM | 0.0278 mL | 0.1391 mL | 0.2782 mL | 0.6955 mL | |
| 40 mM | 0.0209 mL | 0.1043 mL | 0.2086 mL | 0.5216 mL | |
| 50 mM | 0.0167 mL | 0.0835 mL | 0.1669 mL | 0.4173 mL | |
| 60 mM | 0.0139 mL | 0.0695 mL | 0.1391 mL | 0.3477 mL | |
| 80 mM | 0.0104 mL | 0.0522 mL | 0.1043 mL | 0.2608 mL |
NR-11c Related Classifications
HY-159798 Related Classifications
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