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Art. -Nr.: HY-138976

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NV-5440

NV-5440 (Compound I-120) is an mTORC1 inhibitor and glucose transporter inhibitor. NV-5440 targets GLUT-1, -2, -3, and -4, and shows no activity against GLUT-5. NV-5440 inhibits glucose uptake.

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CAS. Nr.: 2226614-88-4
Formel: C₃₁H₃₆N₆O₃S
Molecular Weight:572.73

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NV-5440 Chemical Structure

CAS. Nr.: 2226614-88-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

mTORC1

GLUT1

GLUT2

GLUT3

GLUT4

Alle mTOR Isoform-spezifische Produkte anzeigen :

Alle GLUT Isoform-spezifische Produkte anzeigen :

In Vitro

NV-5440 potently inhibits ³H-2DG uptake in MCF7 cells with an IC₅₀ of 36 nM, and targets GLUT-1 through GLUT-4 but not GLUT-5^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NV-5440 (30 mg/kg; i.p.) inhibits mTORC1 activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[2]
Dosage:

30 mg/kg
Administration:

i.p.
Result:

Confirmed inhibition of
mTORC1 activity.

Chemical Information

CAS. Nr. 2226614-88-4
Molecular Weight 572.73
Formel C₃₁H₃₆N₆O₃S
SMILES

N#CC=1C=CC=CC1N2CCN(CC3=CC(C(=O)N4CCN(C=5C=CC=CC5S(=O)(=O)N)CC4)=C(C=C3C)C)CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. David John O'neill, et al. PHENYL mTORC INHIBITORS AND USES THEREOF. WO2018089433A1. https://patents.google.com/patent/WO2018089433A1/en?oq=WO2018089433+A1

[2]. Reckzeh ES, et al. Small-Molecule Inhibition of Glucose Transporters GLUT-1-4. Chembiochem. 2020;21(1-2):45-52. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
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NV-5440

Alle mTOR Isoform-spezifische Produkte anzeigen

Alle GLUT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

NV-5440 Related Classifications

HY-138976 Related Classifications