Procaspase-3 activator 1
Procaspase-3 activator 1 is a potent procaspase-3 activator. Procaspase-3 activator directly activates procaspase-3 through zinc chelation, thereby inducing apoptosis and inhibiting cancer cell proliferation. Procaspase-3 activator 1 can be used for the research of non-small cell lung cancer (NSCLC) and melanoma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C23H28N2O5
- Molecular Weight:412.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Procaspase-3 |
Procaspase-3 activator 1 (compound K-15) (24 h) demonstrates potent antiproliferative activity against A549 and A375 cells with IC50s of 3.96 and 21.18 µM, while maintaining negligible cytotoxicity against BEAS-2B cells at 10 μM, indicating its selectivity[1].
Procaspase-3 activator 1 (50 μM, 0-180 min) can directly activate procaspase-3 into caspase-3, exhibiting superior activation activity compared to the positive control PAC-1 (HY-13523)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 412.48
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Formel C23H28N2O5
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SMILES
CCCCCCOC1=C(C=C(C=C1)/C=N/NC(/C=C/C2=CC(O)=C(C=C2)O)=O)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Procaspase-3 activator 1 Related Classifications
HY-179699 Related Classifications
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