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Art. -Nr.: HY-164527

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Si306

Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM).

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CAS. Nr.: 1640012-88-9
Formel: C₂₅H₂₆BrClN₆OS
Molecular Weight:573.94

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Si306 Chemical Structure

CAS. Nr.: 1640012-88-9

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Src Isoform-spezifische Produkte anzeigen :

Alle EGFR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	IC₅₀	0.34 μM Compound: 29	Antiproliferative activity against human SH-SY5Y cells after 24 hrs Antiproliferative activity against human SH-SY5Y cells after 24 hrs	[PMID: 25469771]
U-87MG ATCC	IC₅₀	1.9 μM Compound: 4	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by trypan blue assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by trypan blue assay	[PMID: 28650650]
U-87MG ATCC	IC₅₀	17.3 μM Compound: 4	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs by trypan blue assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs by trypan blue assay	[PMID: 28650650]
U-87MG ATCC	IC₅₀	6.8 μM Compound: 4	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 48 hrs by trypan blue assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 48 hrs by trypan blue assay	[PMID: 28650650]

Chemical Information

CAS. Nr. 1640012-88-9
Molecular Weight 573.94
Formel C₂₅H₂₆BrClN₆OS
SMILES

BrC1=CC(NC2=NC(SCCN3CCOCC3)=NC4=C2C=NN4CC(Cl)C5=CC=CC=C5)=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nešović, et al. "Src Inhibitors Pyrazolo [3, 4-d] pyrimidines, Si306 and Pro-Si306, inhibit focal adhesion kinase and suppress human glioblastoma invasion in vitro and in vivo." Cancers 12.6 (2020): 1570. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
Chemical Information
Reinheit & Dokumentation
Verweise

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Si306

Alle Src Isoform-spezifische Produkte anzeigen

Alle EGFR Isoform-spezifische Produkte anzeigen