Art. -Nr.: HY-N7652

Terminolic acid

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Terminolic acid is a pentacyclic triterpene glycoside and antibacterial agent. Terminolic acid can be isolated from Combretum racemosum. Terminolic acid inhibits proinflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6. Terminolic acid reduces IL-8. Terminolic acid has antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis with MICs ranging from 64 to 256 μg/mL. Terminolic acid is used in colon cancer research.

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Reinheit: 99.92%
CAS. Nr.: 564-13-6
Formel: C₃₀H₄₈O₆
Molecular Weight:504.70

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Terminolic acid Chemical Structure

CAS. Nr.: 564-13-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]^[2]^[3]

IL-8

IL-6

IL-1β

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

Terminolic acid shows moderate antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis with MICs ranging from 64 to 256 μg/mL^[1].
Terminolic acid (63.9 μM) reduces the production of IL-8 to 35% in human colon cancer cells HT-29^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 564-13-6
Appearance Solid
Molecular Weight 504.70
Formel C₃₀H₄₈O₆
Color White to off-white
SMILES

C[C@@]1(C[C@H]2O)[C@@](CC=C([C@]3([H])CC4(C)C)[C@]1(CC[C@]3(CC4)C(O)=O)C)([H])[C@]([C@]2([H])[C@@](C)([C@H]5O)CO)(C[C@H]5O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (198.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9814 mL

9.9069 mL

19.8138 mL

5 mM

0.3963 mL

1.9814 mL

3.9628 mL

10 mM

0.1981 mL

0.9907 mL

1.9814 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gossan DPA, et, al. Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum. Fitoterapia. 2016 Apr;110:89-95. [Content Brief]

[2]. Legiawati L, et, al. In silico study of Centella asiatica active compounds as anti-inflammatory agent by decreasing Il-1 and Il-6 activity, promoting Il-4 activity. /J. Pharm. Sci. & Res. Vol. 10(9), 2018, 2142-2147.

[3]. Yang GX, et al. Chemical constituents from Melastoma dodecandrum and their inhibitory activity on interleukin-8 production in HT-29 cells. Nat Prod Res. 2014;28(17):1383-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9814 mL	9.9069 mL	19.8138 mL	49.5344 mL
	5 mM	0.3963 mL	1.9814 mL	3.9628 mL	9.9069 mL
	10 mM	0.1981 mL	0.9907 mL	1.9814 mL	4.9534 mL
	15 mM	0.1321 mL	0.6605 mL	1.3209 mL	3.3023 mL
	20 mM	0.0991 mL	0.4953 mL	0.9907 mL	2.4767 mL
	25 mM	0.0793 mL	0.3963 mL	0.7926 mL	1.9814 mL
	30 mM	0.0660 mL	0.3302 mL	0.6605 mL	1.6511 mL
	40 mM	0.0495 mL	0.2477 mL	0.4953 mL	1.2384 mL
	50 mM	0.0396 mL	0.1981 mL	0.3963 mL	0.9907 mL
	60 mM	0.0330 mL	0.1651 mL	0.3302 mL	0.8256 mL
	80 mM	0.0248 mL	0.1238 mL	0.2477 mL	0.6192 mL
	100 mM	0.0198 mL	0.0991 mL	0.1981 mL	0.4953 mL

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Terminolic acid

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Anti-Rheumatic Arthritis Compound Library

Mass Spectrometry Natural Product Library

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Terminolic acid

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Anti-Cancer Compound Library

Differentiation Inducing Compound Library

Antibacterial Compound Library

Terpenoids Library

Pyroptosis Compound Library

Angiogenesis-Related Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Cancer Natural Product Library

Antidepressant Compound Library

Plant-Sourced Natural Product Library

Anti-Prostate Cancer Compound Library

Chemokine Compound Library

Pain-Related Compound Library

Autoimmune Disease Compound Library

Cytokine Inhibitors Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Anti-Rheumatic Arthritis Compound Library

Mass Spectrometry Natural Product Library

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Terminolic acid Related Classifications

HY-N7652 Related Classifications