UNC5452
UNC5452 is a selective, ATP-competitive Nek1 kinase inhibitor with an IC50 of 7.1 μM. UNC5452 inhibits IKKβ kinase activity. UNC5452 can be used for research on polycystic kidney disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 943434-15-9
- Formel: C17H20N4O2S
- Molecular Weight:344.43
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
IKKβ |
NEK1 7.1 μM (IC50) |
In Vitro
UNC5452 inhibits recombinant Nek1 in a TR-FRET-based activity assay with an IC50 of 7.1 μM[1].
UNC5452 (1 μM) is a potent and selective Nek1 inhibitor (99.8% inhibition at 1 μM) with a narrow kinome profile, indicating that the 4-aryl-7-azaindole scaffold is a promising chemical starting point for Nek1-directed development[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 943434-15-9
-
Molecular Weight 344.43
-
Formel C17H20N4O2S
-
SMILES
O=S(=O)(NCCN(C)C)C=1C=CC(=CC1)C=2C=CN=C3NC=CC32
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
UNC5452 Related Classifications
HY-189144 Related Classifications
Powered by Bioz