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Cat. No.: HY-P10027

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Clovibactin

Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors.

For research use only. We do not sell to patients.

CAS No.: 2247194-77-8
Formula: C₄₃H₇₀N₁₀O₁₁
Molecular Weight:903.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Clovibactin Chemical Structure

CAS No.: 2247194-77-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

Clovibactin TFA inhibits Staphylococcus strains with MICs of 0.125-2 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Clovibactin TFA (20 mg/kg, iv, single dose) exhibits a pharmacokinetic profil with a C_max of 219.3 μg/mL, an AUC_{to last} of 31.9 μg·h/mL, t_1/2 of 2 h, CL of 9.4 mL/kg/min and a V_dss of 189.8 mL/kg in mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2247194-77-8
Molecular Weight 903.08
Formula C₄₃H₇₀N₁₀O₁₁
Sequence

Phe-{d-Leu}-{d-Lys}-Ser-{Hyn}-Ala-Leu-Leu (Cyclic ester: Hyn5-Leu8)
Sequence Shortening

F-{d-Leu}-{d-Lys}-S-{Hyn}-ALL (Cyclic ester: Hyn5-Leu8)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shukla R, et al. A new antibiotic from an uncultured bacterium binds to an immutable target. Preprint. bioRxiv. 2023;2023.05.15.540765. Published 2023 May 15. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Clovibactin

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Clovibactin Related Classifications

HY-P10027 Related Classifications