AA-17010
AA-17010 is a Cereblon ligand with an IC50 of 0.20 μM and a Ki of 0.08 μM. AA-17010 serves as an E3 ligase ligand for the synthesis of PROTAC KRAS degraders, such as CW-10201 (HY-189305).
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- CAS No.: 3064305-88-7
- Formule: C19H22N4O4
- Masse moléculaire:370.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Cereblon 0.20 μM (IC50) |
In Vitro
AA-17010 (~3 h) is a high-affinity Cereblon ligand that binds to CRBN with an IC50 of 0.20 μM and a Ki of 0.08 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3064305-88-7
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Masse moléculaire 370.40
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Formule C19H22N4O4
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SMILES
O=C(C(N(C(N(C)C1=C2)=O)C1=CC3=C2C4(CCNCC4)CO3)CC5)NC5=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AA-17010 Related Classifications
HY-189348 Related Classifications
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