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Cat. No.: HY-125747

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Actinomycin X2 (purity≥85%)

(Synonyms: Actinomycin V (purity≥85%))

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection.

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CAS No.: 18865-48-0
Formule: C₆₂H₈₄N₁₂O₁₇
Masse moléculaire:1269.40

Stockage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Actinomycin X2 (purity≥85%) Chemical Structure

CAS No.: 18865-48-0

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Antibiotic :

In Vitro

Actinomycin X2 (1, 10 μM, 24 h) induces apoptosis of human prostate cancer cells by mTOR pathway combined with MiRNA144^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

PC-3
Concentration:

1, 10 μM
Incubation Time:

24 h
Result:

Inhibited the levels of mTOR, PI3K, and Akt.
Increased the level of PTEN.

Apoptosis Analysis^[2]

Cell Line:

PC-3
Concentration:

1, 10 μM
Incubation Time:

24, 48 h
Result:

Increased the apoptotic rate.

Chemical Information

CAS No. 18865-48-0
Appearance Solid
Masse moléculaire 1269.40
Formule C₆₂H₈₄N₁₂O₁₇
Color Orange to red
Synonyms

Actinomycin V (purity≥85%)
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Phytomedicine

2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside ameliorates NAFLD via attenuating hepatic steatosis through inhibiting mitochondrial dysfunction dependent on SIRT5. [Abstract]

2022 Feb 14;99:153994. PMID: 35220131

Solvant et solubilité

In Vitro:

DMSO : 12.7 mg/mL (10.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7878 mL

3.9389 mL

7.8777 mL

5 mM

0.1576 mL

0.7878 mL

1.5755 mL

10 mM

0.0788 mL

0.3939 mL

0.7878 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (281 KB)
SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Portuguese - PT (644 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach ( Periplaneta americana). Front Microbiol. 2020 Apr 7;11:555. [Content Brief]

[2]. Liu J, et al. Apoptosis of human prostate cancer cells induced by marine actinomycin X2 through the mTOR pathway compounded by MiRNA144. Anticancer Drugs. 2016 Mar;27(3):156-63. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.7878 mL	3.9389 mL	7.8777 mL	19.6943 mL
DMSO	5 mM	0.1576 mL	0.7878 mL	1.5755 mL	3.9389 mL

Keywords

Actinomycin X2 (purity≥85%)

1 Cited Publications

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
- In Vivo Dissolution Calculator
Pureté et documentation
Références

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Actinomycin X2 (purity≥85%)

Publications Citing Use of MedChemExpress (MCE) Actinomycin X2 (purity≥85%)

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Actinomycin X2 (purity≥85%) Related Classifications

Cat. No.: HY-125747